| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC94 | CDC5L | ENSP00000262962 | ENSP00000360532 | Coiled-coil domain containing 94 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | 0.987 |
| CCDC94 | CRNKL1 | ENSP00000262962 | ENSP00000366557 | Coiled-coil domain containing 94 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | 0.962 |
| CCDC94 | CWC22 | ENSP00000262962 | ENSP00000387006 | Coiled-coil domain containing 94 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay; Belongs to the CWC22 family | 0.909 |
| CCDC94 | CWC25 | ENSP00000262962 | ENSP00000478070 | Coiled-coil domain containing 94 | CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex | 0.952 |
| CCDC94 | DHX38 | ENSP00000262962 | ENSP00000268482 | Coiled-coil domain containing 94 | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily | 0.953 |
| CCDC94 | PLRG1 | ENSP00000262962 | ENSP00000424417 | Coiled-coil domain containing 94 | Pleiotropic regulator 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.993 |
| CCDC94 | PRPF19 | ENSP00000262962 | ENSP00000227524 | Coiled-coil domain containing 94 | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates ’Lys-63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruite [...] | 0.975 |
| CCDC94 | SNW1 | ENSP00000262962 | ENSP00000261531 | Coiled-coil domain containing 94 | SNW domain-containing protein 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coac [...] | 0.914 |
| CCDC94 | SYF2 | ENSP00000262962 | ENSP00000236273 | Coiled-coil domain containing 94 | Pre-mRNA-splicing factor SYF2; May be involved in pre-mRNA splicing; Belongs to the SYF2 family | 0.959 |
| CCDC94 | XAB2 | ENSP00000262962 | ENSP00000351137 | Coiled-coil domain containing 94 | Pre-mRNA-splicing factor SYF1; Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing; Belongs to the crooked-neck family | 0.960 |
| CDC5L | CCDC94 | ENSP00000360532 | ENSP00000262962 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | Coiled-coil domain containing 94 | 0.987 |
| CDC5L | CRNKL1 | ENSP00000360532 | ENSP00000366557 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | 0.999 |
| CDC5L | CWC22 | ENSP00000360532 | ENSP00000387006 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay; Belongs to the CWC22 family | 0.999 |
| CDC5L | CWC25 | ENSP00000360532 | ENSP00000478070 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex | 0.995 |
| CDC5L | DHX38 | ENSP00000360532 | ENSP00000268482 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily | 0.996 |
| CDC5L | PLRG1 | ENSP00000360532 | ENSP00000424417 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | Pleiotropic regulator 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.999 |
| CDC5L | PRPF19 | ENSP00000360532 | ENSP00000227524 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates ’Lys-63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruite [...] | 0.999 |
| CDC5L | SNW1 | ENSP00000360532 | ENSP00000261531 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | SNW domain-containing protein 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coac [...] | 0.999 |
| CDC5L | SYF2 | ENSP00000360532 | ENSP00000236273 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | Pre-mRNA-splicing factor SYF2; May be involved in pre-mRNA splicing; Belongs to the SYF2 family | 0.999 |
| CDC5L | XAB2 | ENSP00000360532 | ENSP00000351137 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | Pre-mRNA-splicing factor SYF1; Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing; Belongs to the crooked-neck family | 0.999 |
