| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CNPY1 | CNPY4 | ENSP00000317439 | ENSP00000262932 | Canopy FGF signaling regulator 1; Belongs to the canopy family | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4 | 0.622 |
| CNPY1 | LRRC40 | ENSP00000317439 | ENSP00000359990 | Canopy FGF signaling regulator 1; Belongs to the canopy family | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40 | 0.589 |
| CNPY4 | CNPY1 | ENSP00000262932 | ENSP00000317439 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4 | Canopy FGF signaling regulator 1; Belongs to the canopy family | 0.622 |
| CNPY4 | GAL3ST1 | ENSP00000262932 | ENSP00000385735 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4 | Galactosylceramide sulfotransferase; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro); Belongs to the galactose-3-O-sulfotransferase family | 0.674 |
| CNPY4 | GLRX3 | ENSP00000262932 | ENSP00000357633 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4 | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity; Glutaredoxin domain containing | 0.656 |
| CNPY4 | HSPA4L | ENSP00000262932 | ENSP00000296464 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4 | Heat shock 70 kDa protein 4L; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase; Belongs to the heat shock protein 70 family | 0.565 |
| CNPY4 | LRIG2 | ENSP00000262932 | ENSP00000355396 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4 | Leucine rich repeats and immunoglobulin like domains 2; I-set domain containing | 0.660 |
| CNPY4 | LRRC40 | ENSP00000262932 | ENSP00000359990 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4 | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40 | 0.745 |
| CNPY4 | LY96 | ENSP00000262932 | ENSP00000284818 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4 | Lymphocyte antigen 96; Binds bacterial lipopolysaccharide (LPS). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram- positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS | 0.648 |
| CNPY4 | RSPH1 | ENSP00000262932 | ENSP00000291536 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4 | Radial spoke head 1 homolog; May play an important role in male meiosis (By similarity). It is necessary for proper building of the axonemal central pair and radial spokes | 0.575 |
| CNPY4 | THEG | ENSP00000262932 | ENSP00000340088 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4 | Testicular haploid expressed gene protein; May be involved (but not essential) in spermatogenesis | 0.596 |
| CNPY4 | TLR4 | ENSP00000262932 | ENSP00000363089 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific. Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression. In complex with T [...] | 0.707 |
| GAL3ST1 | CNPY4 | ENSP00000385735 | ENSP00000262932 | Galactosylceramide sulfotransferase; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro); Belongs to the galactose-3-O-sulfotransferase family | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4 | 0.674 |
| GAL3ST1 | GLRX3 | ENSP00000385735 | ENSP00000357633 | Galactosylceramide sulfotransferase; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro); Belongs to the galactose-3-O-sulfotransferase family | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity; Glutaredoxin domain containing | 0.660 |
| GAL3ST1 | LRIG2 | ENSP00000385735 | ENSP00000355396 | Galactosylceramide sulfotransferase; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro); Belongs to the galactose-3-O-sulfotransferase family | Leucine rich repeats and immunoglobulin like domains 2; I-set domain containing | 0.628 |
| GAL3ST1 | LRRC40 | ENSP00000385735 | ENSP00000359990 | Galactosylceramide sulfotransferase; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro); Belongs to the galactose-3-O-sulfotransferase family | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40 | 0.702 |
| GLRX3 | CNPY4 | ENSP00000357633 | ENSP00000262932 | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity; Glutaredoxin domain containing | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4 | 0.656 |
| GLRX3 | GAL3ST1 | ENSP00000357633 | ENSP00000385735 | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity; Glutaredoxin domain containing | Galactosylceramide sulfotransferase; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro); Belongs to the galactose-3-O-sulfotransferase family | 0.660 |
| GLRX3 | LRIG2 | ENSP00000357633 | ENSP00000355396 | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity; Glutaredoxin domain containing | Leucine rich repeats and immunoglobulin like domains 2; I-set domain containing | 0.593 |
| GLRX3 | LRRC40 | ENSP00000357633 | ENSP00000359990 | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity; Glutaredoxin domain containing | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40 | 0.688 |
