• Version:
  • 11.0 [archived version]
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TMCO3 TMCO3 RGAG1 RGAG1 CCDC25 CCDC25 TMEM164 TMEM164 AMMECR1 AMMECR1 GUCY2F GUCY2F THOC2 THOC2 NXT2 NXT2 KCNE1L KCNE1L ACSL4 ACSL4 COL4A5 COL4A5
"AMMECR1" - AMME syndrome candidate gene 1 protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
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Cooccurence
Coexpression
Experiments
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[Homology]
Score
AMMECR1AMME syndrome candidate gene 1 protein; Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 (333 aa)    
Predicted Functional Partners:
ACSL4
Long-chain-fatty-acid--CoA ligase 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates; Acyl-CoA synthetase family (711 aa)
     
   
  0.921
COL4A5
Collagen alpha-5(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen; Collagens (1691 aa)
     
   
  0.833
KCNE1L
Potassium voltage-gated channel subfamily E regulatory beta subunit 5; Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1 (142 aa)
     
   
  0.807
GUCY2F
Retinal guanylyl cyclase 2; Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction; Guanylate cyclase receptors (1108 aa)
     
   
  0.754
NXT2
NTF2-related export protein 2; Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export (197 aa)
     
   
  0.746
RGAG1
Retrotransposon Gag-like protein 9; Retrotransposon gag domain containing 1 (1388 aa)
     
   
  0.690
TMEM164
Transmembrane protein 164; Belongs to the TMEM164 family (297 aa)
     
   
  0.678
THOC2
THO complex subunit 2; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export to the cyt [...] (1593 aa)
     
   
  0.660
TMCO3
Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family (677 aa)
           
  0.637
CCDC25
Coiled-coil domain containing 25; Belongs to the CCDC25 family (208 aa)
           
  0.629
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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