MID2 protein (human) - STRING database

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MID2

Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization; Belongs to the TRIM/RBCC family (735 aa)

Predicted Functional Partners:

SURF6

0.756

COL4A6

0.721

TRAT1

0.684

PRSS50

0.654

PRPS1

0.654

PRPS1L1

0.650

PRPS2

0.646

ARHGAP6

0.644

PML

0.627

TRIM5

0.585

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP6	MID2	ENSP00000338967	ENSP00000262843	Rho GTPase-activating protein 6; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology	Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization; Belongs to the TRIM/RBCC family	0.644
COL4A6	MID2	ENSP00000378340	ENSP00000262843	Collagen alpha-6(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen	Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization; Belongs to the TRIM/RBCC family	0.721
COL4A6	PRPS1	ENSP00000378340	ENSP00000361512	Collagen alpha-6(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen	Ribose-phosphate pyrophosphokinase 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase family	0.573
COL4A6	PRPS1L1	ENSP00000378340	ENSP00000424595	Collagen alpha-6(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen	Ribose-phosphate pyrophosphokinase 3; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis	0.626
COL4A6	PRPS2	ENSP00000378340	ENSP00000381504	Collagen alpha-6(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen	Ribose-phosphate pyrophosphokinase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase family	0.579
MID2	ARHGAP6	ENSP00000262843	ENSP00000338967	Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization; Belongs to the TRIM/RBCC family	Rho GTPase-activating protein 6; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology	0.644
MID2	COL4A6	ENSP00000262843	ENSP00000378340	Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization; Belongs to the TRIM/RBCC family	Collagen alpha-6(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen	0.721
MID2	PML	ENSP00000262843	ENSP00000268058	Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization; Belongs to the TRIM/RBCC family	Protein PML; Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression- activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respe [...]	0.627
MID2	PRPS1	ENSP00000262843	ENSP00000361512	Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization; Belongs to the TRIM/RBCC family	Ribose-phosphate pyrophosphokinase 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase family	0.654
MID2	PRPS1L1	ENSP00000262843	ENSP00000424595	Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization; Belongs to the TRIM/RBCC family	Ribose-phosphate pyrophosphokinase 3; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis	0.650
MID2	PRPS2	ENSP00000262843	ENSP00000381504	Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization; Belongs to the TRIM/RBCC family	Ribose-phosphate pyrophosphokinase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase family	0.646
MID2	PRSS50	ENSP00000262843	ENSP00000418875	Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization; Belongs to the TRIM/RBCC family	Probable threonine protease PRSS50; May be involved in proteolysis through its threonine endopeptidase activity; Belongs to the peptidase S1 family	0.654
MID2	SURF6	ENSP00000262843	ENSP00000361092	Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization; Belongs to the TRIM/RBCC family	Surfeit locus protein 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity)	0.756
MID2	TRAT1	ENSP00000262843	ENSP00000295756	Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization; Belongs to the TRIM/RBCC family	T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells	0.684
MID2	TRIM5	ENSP00000262843	ENSP00000369373	Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization; Belongs to the TRIM/RBCC family	Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also [...]	0.585
PML	MID2	ENSP00000268058	ENSP00000262843	Protein PML; Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression- activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respe [...]	Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization; Belongs to the TRIM/RBCC family	0.627
PML	TRAT1	ENSP00000268058	ENSP00000295756	Protein PML; Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression- activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respe [...]	T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells	0.674
PML	TRIM5	ENSP00000268058	ENSP00000369373	Protein PML; Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression- activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respe [...]	Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also [...]	0.953
PRPS1	COL4A6	ENSP00000361512	ENSP00000378340	Ribose-phosphate pyrophosphokinase 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase family	Collagen alpha-6(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen	0.573
PRPS1	MID2	ENSP00000361512	ENSP00000262843	Ribose-phosphate pyrophosphokinase 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase family	Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization; Belongs to the TRIM/RBCC family	0.654

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