| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCM2L | DUSP15 | ENSP00000262659 | ENSP00000341658 | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6; Atypical dual specificity phosphatases | 0.566 |
| CCM2L | HEG1 | ENSP00000262659 | ENSP00000311502 | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | Protein HEG homolog 1; Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions | 0.611 |
| CCM2L | KIF3B | ENSP00000262659 | ENSP00000364864 | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | Kinesin-like protein KIF3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Kinesins | 0.508 |
| CCM2L | KRIT1 | ENSP00000262659 | ENSP00000378015 | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and va [...] | 0.899 |
| CCM2L | MAP3K3 | ENSP00000262659 | ENSP00000354927 | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | Mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators | 0.608 |
| CCM2L | PDCD10 | ENSP00000262659 | ENSP00000376506 | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity); Belongs to the PDCD10 family | 0.741 |
| CCM2L | POFUT1 | ENSP00000262659 | ENSP00000364902 | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can [...] | 0.581 |
| CCM2L | RAP2A | ENSP00000262659 | ENSP00000245304 | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | Ras-related protein Rap-2a; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading; RAS type GTPase family | 0.587 |
| CCM2L | STRN | ENSP00000262659 | ENSP00000263918 | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | Striatin; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling; Belongs to the WD repeat striatin family | 0.649 |
| CCM2L | XKR7 | ENSP00000262659 | ENSP00000477059 | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | XK-related protein 7; XK related family | 0.712 |
| DUSP15 | CCM2L | ENSP00000341658 | ENSP00000262659 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6; Atypical dual specificity phosphatases | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | 0.566 |
| DUSP15 | XKR7 | ENSP00000341658 | ENSP00000477059 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6; Atypical dual specificity phosphatases | XK-related protein 7; XK related family | 0.645 |
| HEG1 | CCM2L | ENSP00000311502 | ENSP00000262659 | Protein HEG homolog 1; Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | 0.611 |
| HEG1 | KRIT1 | ENSP00000311502 | ENSP00000378015 | Protein HEG homolog 1; Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and va [...] | 0.993 |
| HEG1 | PDCD10 | ENSP00000311502 | ENSP00000376506 | Protein HEG homolog 1; Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions | Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity); Belongs to the PDCD10 family | 0.612 |
| HEG1 | RAP2A | ENSP00000311502 | ENSP00000245304 | Protein HEG homolog 1; Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions | Ras-related protein Rap-2a; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading; RAS type GTPase family | 0.593 |
| KIF3B | CCM2L | ENSP00000364864 | ENSP00000262659 | Kinesin-like protein KIF3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Kinesins | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | 0.508 |
| KIF3B | POFUT1 | ENSP00000364864 | ENSP00000364902 | Kinesin-like protein KIF3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Kinesins | GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can [...] | 0.535 |
| KIF3B | XKR7 | ENSP00000364864 | ENSP00000477059 | Kinesin-like protein KIF3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Kinesins | XK-related protein 7; XK related family | 0.494 |
| KRIT1 | CCM2L | ENSP00000378015 | ENSP00000262659 | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and va [...] | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | 0.899 |
