| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CRNKL1 | HNRNPK | ENSP00000366557 | ENSP00000365439 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription [...] | 0.906 |
| CRNKL1 | PRPF31 | ENSP00000366557 | ENSP00000324122 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | 0.942 |
| CRNKL1 | PRPF6 | ENSP00000366557 | ENSP00000266079 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | Pre-mRNA-processing factor 6; Involved in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation; U5 small nucleolar ribonucleoprotein | 0.935 |
| CRNKL1 | RBM42 | ENSP00000366557 | ENSP00000262633 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | RNA-binding protein 42; Binds (via the RRM domain) to the 3’-untranslated region (UTR) of CDKN1A mRNA; RNA binding motif containing | 0.594 |
| CRNKL1 | SART1 | ENSP00000366557 | ENSP00000310448 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | U4/U6.U5 tri-snRNP-associated protein 1; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA; Belongs to the SNU66/SART1 family | 0.986 |
| CRNKL1 | SNRPA | ENSP00000366557 | ENSP00000243563 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | U1 small nuclear ribonucleoprotein A; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5’-UGCAC-3’ motif on RNAs; Belongs to the RRM U1 A/B’’ family | 0.974 |
| DTD2 | ERP29 | ENSP00000312224 | ENSP00000261735 | Putative D-tyrosyl-tRNA(Tyr) deacylase 2; May D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential) | Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER | 0.522 |
| DTD2 | RBM42 | ENSP00000312224 | ENSP00000262633 | Putative D-tyrosyl-tRNA(Tyr) deacylase 2; May D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential) | RNA-binding protein 42; Binds (via the RRM domain) to the 3’-untranslated region (UTR) of CDKN1A mRNA; RNA binding motif containing | 0.724 |
| DTD2 | TMEM9 | ENSP00000312224 | ENSP00000356301 | Putative D-tyrosyl-tRNA(Tyr) deacylase 2; May D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential) | Transmembrane protein 9; May be involved in intracellular transport | 0.700 |
| ERP29 | DTD2 | ENSP00000261735 | ENSP00000312224 | Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER | Putative D-tyrosyl-tRNA(Tyr) deacylase 2; May D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential) | 0.522 |
| ERP29 | RBM42 | ENSP00000261735 | ENSP00000262633 | Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER | RNA-binding protein 42; Binds (via the RRM domain) to the 3’-untranslated region (UTR) of CDKN1A mRNA; RNA binding motif containing | 0.610 |
| ERP29 | TMEM9 | ENSP00000261735 | ENSP00000356301 | Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER | Transmembrane protein 9; May be involved in intracellular transport | 0.548 |
| FASTKD2 | RBM42 | ENSP00000236980 | ENSP00000262633 | FAST kinase domain-containing protein 2, mitochondrial; Plays an important role in assembly of the mitochondrial large ribosomal subunit; FASTK mitochondrial RNA binding family | RNA-binding protein 42; Binds (via the RRM domain) to the 3’-untranslated region (UTR) of CDKN1A mRNA; RNA binding motif containing | 0.679 |
| HNRNPK | CRNKL1 | ENSP00000365439 | ENSP00000366557 | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription [...] | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | 0.906 |
| HNRNPK | PRPF31 | ENSP00000365439 | ENSP00000324122 | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription [...] | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | 0.915 |
| HNRNPK | PRPF6 | ENSP00000365439 | ENSP00000266079 | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription [...] | Pre-mRNA-processing factor 6; Involved in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation; U5 small nucleolar ribonucleoprotein | 0.940 |
| HNRNPK | RBM42 | ENSP00000365439 | ENSP00000262633 | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription [...] | RNA-binding protein 42; Binds (via the RRM domain) to the 3’-untranslated region (UTR) of CDKN1A mRNA; RNA binding motif containing | 0.941 |
| HNRNPK | SART1 | ENSP00000365439 | ENSP00000310448 | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription [...] | U4/U6.U5 tri-snRNP-associated protein 1; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA; Belongs to the SNU66/SART1 family | 0.928 |
| HNRNPK | SNRPA | ENSP00000365439 | ENSP00000243563 | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription [...] | U1 small nuclear ribonucleoprotein A; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5’-UGCAC-3’ motif on RNAs; Belongs to the RRM U1 A/B’’ family | 0.977 |
| PRPF31 | CRNKL1 | ENSP00000324122 | ENSP00000366557 | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family | 0.942 |
