| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CA6 | CHST8 | ENSP00000366654 | ENSP00000262622 | Carbonic anhydrase 6; Reversible hydration of carbon dioxide. Its role in saliva is unknown; Carbonic anhydrases | Carbohydrate sulfotransferase 8; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin; Belongs to the sulfotransferase 2 family | 0.807 |
| CA6 | CHST9 | ENSP00000366654 | ENSP00000480991 | Carbonic anhydrase 6; Reversible hydration of carbon dioxide. Its role in saliva is unknown; Carbonic anhydrases | Carbohydrate sulfotransferase 9; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin; Sulfotransferases, membrane bound | 0.801 |
| CA6 | LHB | ENSP00000366654 | ENSP00000221421 | Carbonic anhydrase 6; Reversible hydration of carbon dioxide. Its role in saliva is unknown; Carbonic anhydrases | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids; Endogenous ligands | 0.468 |
| CCDC174 | CHST8 | ENSP00000373304 | ENSP00000262622 | Coiled-coil domain-containing protein 174; Probably involved in neuronal development | Carbohydrate sulfotransferase 8; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin; Belongs to the sulfotransferase 2 family | 0.629 |
| CCDC174 | CHST9 | ENSP00000373304 | ENSP00000480991 | Coiled-coil domain-containing protein 174; Probably involved in neuronal development | Carbohydrate sulfotransferase 9; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin; Sulfotransferases, membrane bound | 0.405 |
| CCDC174 | GPR22 | ENSP00000373304 | ENSP00000302676 | Coiled-coil domain-containing protein 174; Probably involved in neuronal development | Probable G-protein coupled receptor 22; Orphan receptor; G protein-coupled receptors, Class A orphans | 0.692 |
| CGA | CHST8 | ENSP00000482232 | ENSP00000262622 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Carbohydrate sulfotransferase 8; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin; Belongs to the sulfotransferase 2 family | 0.900 |
| CGA | LHB | ENSP00000482232 | ENSP00000221421 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids; Endogenous ligands | 0.981 |
| CHST8 | CA6 | ENSP00000262622 | ENSP00000366654 | Carbohydrate sulfotransferase 8; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin; Belongs to the sulfotransferase 2 family | Carbonic anhydrase 6; Reversible hydration of carbon dioxide. Its role in saliva is unknown; Carbonic anhydrases | 0.807 |
| CHST8 | CCDC174 | ENSP00000262622 | ENSP00000373304 | Carbohydrate sulfotransferase 8; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin; Belongs to the sulfotransferase 2 family | Coiled-coil domain-containing protein 174; Probably involved in neuronal development | 0.629 |
| CHST8 | CGA | ENSP00000262622 | ENSP00000482232 | Carbohydrate sulfotransferase 8; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin; Belongs to the sulfotransferase 2 family | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | 0.900 |
| CHST8 | CHST9 | ENSP00000262622 | ENSP00000480991 | Carbohydrate sulfotransferase 8; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin; Belongs to the sulfotransferase 2 family | Carbohydrate sulfotransferase 9; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin; Sulfotransferases, membrane bound | 0.815 |
| CHST8 | CSTA | ENSP00000262622 | ENSP00000264474 | Carbohydrate sulfotransferase 8; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin; Belongs to the sulfotransferase 2 family | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family | 0.535 |
| CHST8 | GCNT2 | ENSP00000262622 | ENSP00000368917 | Carbohydrate sulfotransferase 8; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin; Belongs to the sulfotransferase 2 family | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells; Belongs to the glycosyltransferase 14 family | 0.583 |
| CHST8 | GPR22 | ENSP00000262622 | ENSP00000302676 | Carbohydrate sulfotransferase 8; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin; Belongs to the sulfotransferase 2 family | Probable G-protein coupled receptor 22; Orphan receptor; G protein-coupled receptors, Class A orphans | 0.587 |
| CHST8 | HS3ST3A1 | ENSP00000262622 | ENSP00000284110 | Carbohydrate sulfotransferase 8; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin; Belongs to the sulfotransferase 2 family | Heparan sulfate glucosamine 3-O-sulfotransferase 3A1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non- anticoagulant heparan sulfate to anti [...] | 0.535 |
| CHST8 | LHB | ENSP00000262622 | ENSP00000221421 | Carbohydrate sulfotransferase 8; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin; Belongs to the sulfotransferase 2 family | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids; Endogenous ligands | 0.928 |
| CHST8 | PRR32 | ENSP00000262622 | ENSP00000360166 | Carbohydrate sulfotransferase 8; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin; Belongs to the sulfotransferase 2 family | Proline-rich protein 32; Proline rich 32 | 0.555 |
| CHST9 | CA6 | ENSP00000480991 | ENSP00000366654 | Carbohydrate sulfotransferase 9; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin; Sulfotransferases, membrane bound | Carbonic anhydrase 6; Reversible hydration of carbon dioxide. Its role in saliva is unknown; Carbonic anhydrases | 0.801 |
| CHST9 | CCDC174 | ENSP00000480991 | ENSP00000373304 | Carbohydrate sulfotransferase 9; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin; Sulfotransferases, membrane bound | Coiled-coil domain-containing protein 174; Probably involved in neuronal development | 0.405 |
