• Version:
  • 11.0 [archived version]
STRINGSTRING
TMEM88B TMEM88B OVOL2 OVOL2 CPNE9 CPNE9 LONRF2 LONRF2 DZANK1 DZANK1 RNFT2 RNFT2 ZNF133 ZNF133 DIRAS1 DIRAS1 ZCCHC18 ZCCHC18 LRRC40 LRRC40 RBBP9 RBBP9
"DZANK1" - Double zinc ribbon and ankyrin repeat domains 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DZANK1Double zinc ribbon and ankyrin repeat domains 1 (752 aa)    
Predicted Functional Partners:
RBBP9
Putative hydrolase RBBP9; May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1; Belongs to the RBBP9 family (186 aa)
 
       
  0.728
ZCCHC18
Zinc finger CCHC-type containing 18; Belongs to the ZCCHC12 family (403 aa)
     
   
  0.563
LONRF2
LON peptidase N-terminal domain and ring finger 2 (754 aa)
     
   
  0.553
LRRC40
Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40 (602 aa)
           
  0.553
TMEM88B
Transmembrane protein 88B (163 aa)
     
   
  0.551
CPNE9
Copine-9; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes; Copines (553 aa)
     
   
  0.542
RNFT2
Ring finger protein, transmembrane 2 (444 aa)
     
   
  0.542
OVOL2
Transcription factor Ovo-like 2; Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos (By similarity); Belongs to the krueppel C2H2-type zinc-finger prot [...] (275 aa)
           
  0.512
ZNF133
Zinc finger protein 133; May be involved in transcriptional regulation as a repressor; Zinc fingers C2H2-type (667 aa)
           
  0.510
DIRAS1
GTP-binding protein Di-Ras1; Displays low GTPase activity and exists predominantly in the GTP-bound form; RAS type GTPase family (198 aa)
     
   
  0.461
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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