| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHGA | CPE | ENSP00000216492 | ENSP00000386104 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin; Belongs to the peptidase M14 family | 0.648 |
| CHGA | IAPP | ENSP00000216492 | ENSP00000240652 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family | 0.493 |
| CHGA | INS | ENSP00000216492 | ENSP00000380432 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver | 0.684 |
| CHGA | PCSK2 | ENSP00000216492 | ENSP00000262545 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells; Belongs to the peptidase S8 family. Furin subfamily | 0.662 |
| CHGA | SCG5 | ENSP00000216492 | ENSP00000300175 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro; Granins | 0.669 |
| CHGA | SYT11 | ENSP00000216492 | ENSP00000357307 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Synaptotagmin-11; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis; Belongs to the synaptotagmin family | 0.442 |
| CHGA | SYT4 | ENSP00000216492 | ENSP00000255224 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Synaptotagmin-4; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes; Belongs to the synaptotagmin family | 0.697 |
| CPE | CHGA | ENSP00000386104 | ENSP00000216492 | Carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin; Belongs to the peptidase M14 family | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | 0.648 |
| CPE | IAPP | ENSP00000386104 | ENSP00000240652 | Carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin; Belongs to the peptidase M14 family | Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family | 0.442 |
| CPE | INS | ENSP00000386104 | ENSP00000380432 | Carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin; Belongs to the peptidase M14 family | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver | 0.970 |
| CPE | PCSK2 | ENSP00000386104 | ENSP00000262545 | Carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin; Belongs to the peptidase M14 family | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells; Belongs to the peptidase S8 family. Furin subfamily | 0.917 |
| CPE | SCG5 | ENSP00000386104 | ENSP00000300175 | Carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin; Belongs to the peptidase M14 family | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro; Granins | 0.731 |
| CPE | SYT4 | ENSP00000386104 | ENSP00000255224 | Carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin; Belongs to the peptidase M14 family | Synaptotagmin-4; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes; Belongs to the synaptotagmin family | 0.441 |
| CPN1 | PCSK2 | ENSP00000359446 | ENSP00000262545 | Carboxypeptidase N catalytic chain; Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation; M14 carboxypeptidases | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells; Belongs to the peptidase S8 family. Furin subfamily | 0.710 |
| CPZ | PCSK2 | ENSP00000354255 | ENSP00000262545 | Carboxypeptidase Z; Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing; M14 carboxypeptidases | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells; Belongs to the peptidase S8 family. Furin subfamily | 0.710 |
| IAPP | CHGA | ENSP00000240652 | ENSP00000216492 | Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | 0.493 |
| IAPP | CPE | ENSP00000240652 | ENSP00000386104 | Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family | Carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin; Belongs to the peptidase M14 family | 0.442 |
| IAPP | INS | ENSP00000240652 | ENSP00000380432 | Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver | 0.941 |
| IAPP | PCSK2 | ENSP00000240652 | ENSP00000262545 | Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells; Belongs to the peptidase S8 family. Furin subfamily | 0.689 |
| INS | CHGA | ENSP00000380432 | ENSP00000216492 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | 0.684 |
