node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTR6 | CFDP1 | ENSP00000188312 | ENSP00000283882 | ARP6 actin related protein 6 homolog; Belongs to the actin family. ARP6 subfamily | Craniofacial development protein 1; May play a role during embryogenesis | 0.583 |
ACTR6 | DMAP1 | ENSP00000188312 | ENSP00000361363 | ARP6 actin related protein 6 homolog; Belongs to the actin family. ARP6 subfamily | DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX- mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucl [...] | 0.937 |
ACTR6 | H2AFZ | ENSP00000188312 | ENSP00000296417 | ARP6 actin related protein 6 homolog; Belongs to the actin family. ARP6 subfamily | Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for ch [...] | 0.858 |
ACTR6 | RUVBL1 | ENSP00000188312 | ENSP00000318297 | ARP6 actin related protein 6 homolog; Belongs to the actin family. ARP6 subfamily | RuvB-like 1; May be able to bind plasminogen at cell surface and enhance plasminogen activation; AAA ATPases | 0.788 |
ACTR6 | RUVBL2 | ENSP00000188312 | ENSP00000473172 | ARP6 actin related protein 6 homolog; Belongs to the actin family. ARP6 subfamily | RuvB-like 2; Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes; Belongs to the RuvB family | 0.715 |
ACTR6 | SRCAP | ENSP00000188312 | ENSP00000262518 | ARP6 actin related protein 6 homolog; Belongs to the actin family. ARP6 subfamily | Helicase SRCAP; Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily | 0.956 |
ACTR6 | VPS72 | ENSP00000188312 | ENSP00000346464 | ARP6 actin related protein 6 homolog; Belongs to the actin family. ARP6 subfamily | Vacuolar protein sorting-associated protein 72 homolog; Deposition-and-exchange histone chaperone specific for H2AFZ, specifically chaperones H2AFZ and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP- dependent exchange of histone H2AFZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling | 0.838 |
ACTR6 | YEATS4 | ENSP00000188312 | ENSP00000247843 | ARP6 actin related protein 6 homolog; Belongs to the actin family. ARP6 subfamily | YEATS domain-containing protein 4; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and repl [...] | 0.943 |
ACTR6 | ZNHIT1 | ENSP00000188312 | ENSP00000304593 | ARP6 actin related protein 6 homolog; Belongs to the actin family. ARP6 subfamily | Zinc finger HIT domain-containing protein 1; Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity; Belongs to the ZNHIT1 family | 0.955 |
CFDP1 | ACTR6 | ENSP00000283882 | ENSP00000188312 | Craniofacial development protein 1; May play a role during embryogenesis | ARP6 actin related protein 6 homolog; Belongs to the actin family. ARP6 subfamily | 0.583 |
CFDP1 | DMAP1 | ENSP00000283882 | ENSP00000361363 | Craniofacial development protein 1; May play a role during embryogenesis | DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX- mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucl [...] | 0.992 |
CFDP1 | H2AFZ | ENSP00000283882 | ENSP00000296417 | Craniofacial development protein 1; May play a role during embryogenesis | Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for ch [...] | 0.767 |
CFDP1 | RUVBL1 | ENSP00000283882 | ENSP00000318297 | Craniofacial development protein 1; May play a role during embryogenesis | RuvB-like 1; May be able to bind plasminogen at cell surface and enhance plasminogen activation; AAA ATPases | 0.966 |
CFDP1 | RUVBL2 | ENSP00000283882 | ENSP00000473172 | Craniofacial development protein 1; May play a role during embryogenesis | RuvB-like 2; Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes; Belongs to the RuvB family | 0.959 |
CFDP1 | SRCAP | ENSP00000283882 | ENSP00000262518 | Craniofacial development protein 1; May play a role during embryogenesis | Helicase SRCAP; Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily | 0.920 |
CFDP1 | VPS72 | ENSP00000283882 | ENSP00000346464 | Craniofacial development protein 1; May play a role during embryogenesis | Vacuolar protein sorting-associated protein 72 homolog; Deposition-and-exchange histone chaperone specific for H2AFZ, specifically chaperones H2AFZ and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP- dependent exchange of histone H2AFZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling | 0.908 |
CFDP1 | YEATS4 | ENSP00000283882 | ENSP00000247843 | Craniofacial development protein 1; May play a role during embryogenesis | YEATS domain-containing protein 4; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and repl [...] | 0.877 |
CFDP1 | ZNHIT1 | ENSP00000283882 | ENSP00000304593 | Craniofacial development protein 1; May play a role during embryogenesis | Zinc finger HIT domain-containing protein 1; Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity; Belongs to the ZNHIT1 family | 0.749 |
DMAP1 | ACTR6 | ENSP00000361363 | ENSP00000188312 | DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX- mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucl [...] | ARP6 actin related protein 6 homolog; Belongs to the actin family. ARP6 subfamily | 0.937 |
DMAP1 | CFDP1 | ENSP00000361363 | ENSP00000283882 | DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX- mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucl [...] | Craniofacial development protein 1; May play a role during embryogenesis | 0.992 |