CSPP1 protein (human) - STRING database

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CSPP1

Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization (1221 aa)

Predicted Functional Partners:

FAM110B

0.930

FAM110A

0.930

FAM110C

0.930

DCTN5

0.834

DCTN4

0.813

DCTN3

0.795

CEP41

0.768

OFD1

0.744

DCTN2

0.735

HOMER2

0.730

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEP41	CSPP1	ENSP00000223208	ENSP00000262210	Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium; Belongs to the CEP41 family	Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization	0.768
CEP41	DCTN2	ENSP00000223208	ENSP00000408910	Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium; Belongs to the CEP41 family	Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Dynactin	0.902
CEP41	DCTN3	ENSP00000223208	ENSP00000259632	Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium; Belongs to the CEP41 family	Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis; Dynactin	0.900
CEP41	OFD1	ENSP00000223208	ENSP00000344314	Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium; Belongs to the CEP41 family	Oral-facial-digital syndrome 1 protein; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriol [...]	0.962
CSPP1	CEP41	ENSP00000262210	ENSP00000223208	Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization	Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium; Belongs to the CEP41 family	0.768
CSPP1	DCTN2	ENSP00000262210	ENSP00000408910	Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization	Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Dynactin	0.735
CSPP1	DCTN3	ENSP00000262210	ENSP00000259632	Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization	Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis; Dynactin	0.795
CSPP1	DCTN4	ENSP00000262210	ENSP00000414906	Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization	Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton	0.813
CSPP1	DCTN5	ENSP00000262210	ENSP00000300087	Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization	Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily	0.834
CSPP1	FAM110A	ENSP00000262210	ENSP00000354163	Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization	Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family	0.930
CSPP1	FAM110B	ENSP00000262210	ENSP00000355204	Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization	Protein FAM110B; May be involved in tumor progression	0.930
CSPP1	FAM110C	ENSP00000262210	ENSP00000328347	Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization	Protein FAM110C; May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway	0.930
CSPP1	HOMER2	ENSP00000262210	ENSP00000305632	Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization	Homer protein homolog 2; Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Required for normal hearing; Deafness associated genes	0.730
CSPP1	OFD1	ENSP00000262210	ENSP00000344314	Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization	Oral-facial-digital syndrome 1 protein; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriol [...]	0.744
DCTN2	CEP41	ENSP00000408910	ENSP00000223208	Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Dynactin	Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium; Belongs to the CEP41 family	0.902
DCTN2	CSPP1	ENSP00000408910	ENSP00000262210	Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Dynactin	Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization	0.735
DCTN2	DCTN3	ENSP00000408910	ENSP00000259632	Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Dynactin	Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis; Dynactin	0.995
DCTN2	DCTN4	ENSP00000408910	ENSP00000414906	Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Dynactin	Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton	0.997
DCTN2	DCTN5	ENSP00000408910	ENSP00000300087	Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Dynactin	Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily	0.999
DCTN2	OFD1	ENSP00000408910	ENSP00000344314	Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Dynactin	Oral-facial-digital syndrome 1 protein; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriol [...]	0.915

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