ADNP2 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ADNP2

Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes (1131 aa)

Predicted Functional Partners:

PARD6G

0.626

ENSG00000258644

0.626

CPLX2

0.607

LRIT1

0.587

CBX3

0.584

ARMCX2

0.576

CCDC70

0.574

ARHGAP20

0.572

TMEM63B

0.555

HOMEZ

0.554

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADNP2	ARHGAP20	ENSP00000262198	ENSP00000260283	Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes	Rho GTPase-activating protein 20; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state	0.572
ADNP2	ARMCX2	ENSP00000262198	ENSP00000331662	Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes	Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells; Armadillo repeat containing	0.576
ADNP2	CBX3	ENSP00000262198	ENSP00000336687	Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes	Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 ’Lys-9’ trimethylation, mediates the [...]	0.584
ADNP2	CCDC70	ENSP00000262198	ENSP00000242819	Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes	Coiled-coil domain containing 70	0.574
ADNP2	CPLX2	ENSP00000262198	ENSP00000352544	Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes	Complexin-2; Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity); Belongs to the complexin/synaphin family	0.607
ADNP2	ENSG00000258644	ENSP00000262198	ENSP00000482133	Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes	SYNJ2BP-COX16 readthrough	0.626
ADNP2	HOMEZ	ENSP00000262198	ENSP00000350049	Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes	Homeobox and leucine zipper protein Homez; May function as a transcriptional regulator; ZF class homeoboxes and pseudogenes	0.554
ADNP2	LRIT1	ENSP00000262198	ENSP00000361177	Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction; Fibronectin type III domain containing	0.587
ADNP2	PARD6G	ENSP00000262198	ENSP00000343144	Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes	Partitioning defective 6 homolog gamma; Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP- bound Rho small GTPases to atypical protein kinase C proteins (By similarity); PDZ domain containing	0.626
ADNP2	TMEM63B	ENSP00000262198	ENSP00000259746	Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes	CSC1-like protein 2; Acts as an osmosensitive calcium-permeable cation channel	0.555
ARHGAP20	ADNP2	ENSP00000260283	ENSP00000262198	Rho GTPase-activating protein 20; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state	Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes	0.572
ARHGAP20	ARMCX2	ENSP00000260283	ENSP00000331662	Rho GTPase-activating protein 20; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state	Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells; Armadillo repeat containing	0.666
ARHGAP20	CCDC70	ENSP00000260283	ENSP00000242819	Rho GTPase-activating protein 20; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state	Coiled-coil domain containing 70	0.517
ARHGAP20	TMEM63B	ENSP00000260283	ENSP00000259746	Rho GTPase-activating protein 20; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state	CSC1-like protein 2; Acts as an osmosensitive calcium-permeable cation channel	0.577
ARMCX2	ADNP2	ENSP00000331662	ENSP00000262198	Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells; Armadillo repeat containing	Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes	0.576
ARMCX2	ARHGAP20	ENSP00000331662	ENSP00000260283	Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells; Armadillo repeat containing	Rho GTPase-activating protein 20; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state	0.666
ARMCX2	CCDC70	ENSP00000331662	ENSP00000242819	Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells; Armadillo repeat containing	Coiled-coil domain containing 70	0.593
ARMCX2	TMEM63B	ENSP00000331662	ENSP00000259746	Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells; Armadillo repeat containing	CSC1-like protein 2; Acts as an osmosensitive calcium-permeable cation channel	0.583
CBX3	ADNP2	ENSP00000336687	ENSP00000262198	Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 ’Lys-9’ trimethylation, mediates the [...]	Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes	0.584
CCDC70	ADNP2	ENSP00000242819	ENSP00000262198	Coiled-coil domain containing 70	Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes	0.574

page 1 of 2

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About