| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALS2 | SPAST | ENSP00000264276 | ENSP00000480893 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity); Rho guanine nucleotide exchange factors | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails- severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.461 |
| ALS2 | SPG11 | ENSP00000264276 | ENSP00000261866 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity); Rho guanine nucleotide exchange factors | Spatacsin; May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport | 0.750 |
| AP5B1 | AP5M1 | ENSP00000454303 | ENSP00000261558 | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport; Armadillo-like helical domain containing | AP-5 complex subunit mu-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-18395520, it may play a role in cell death; Belongs to the adaptor complexes medium subunit family | 0.989 |
| AP5B1 | AP5S1 | ENSP00000454303 | ENSP00000481750 | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport; Armadillo-like helical domain containing | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair | 0.993 |
| AP5B1 | AP5Z1 | ENSP00000454303 | ENSP00000297562 | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport; Armadillo-like helical domain containing | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair; Armadillo-like helical domain containing | 0.990 |
| AP5B1 | KIAA0196 | ENSP00000454303 | ENSP00000318016 | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport; Armadillo-like helical domain containing | WASH complex subunit 5; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 | 0.409 |
| AP5B1 | SPG11 | ENSP00000454303 | ENSP00000261866 | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport; Armadillo-like helical domain containing | Spatacsin; May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport | 0.921 |
| AP5B1 | ZFYVE26 | ENSP00000454303 | ENSP00000251119 | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport; Armadillo-like helical domain containing | Zinc finger FYVE domain-containing protein 26; Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis- recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair; Zinc fingers FYVE-type | 0.901 |
| AP5M1 | AP5B1 | ENSP00000261558 | ENSP00000454303 | AP-5 complex subunit mu-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-18395520, it may play a role in cell death; Belongs to the adaptor complexes medium subunit family | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport; Armadillo-like helical domain containing | 0.989 |
| AP5M1 | AP5S1 | ENSP00000261558 | ENSP00000481750 | AP-5 complex subunit mu-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-18395520, it may play a role in cell death; Belongs to the adaptor complexes medium subunit family | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair | 0.989 |
| AP5M1 | AP5Z1 | ENSP00000261558 | ENSP00000297562 | AP-5 complex subunit mu-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-18395520, it may play a role in cell death; Belongs to the adaptor complexes medium subunit family | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair; Armadillo-like helical domain containing | 0.982 |
| AP5M1 | SPG11 | ENSP00000261558 | ENSP00000261866 | AP-5 complex subunit mu-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-18395520, it may play a role in cell death; Belongs to the adaptor complexes medium subunit family | Spatacsin; May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport | 0.842 |
| AP5M1 | ZFYVE26 | ENSP00000261558 | ENSP00000251119 | AP-5 complex subunit mu-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-18395520, it may play a role in cell death; Belongs to the adaptor complexes medium subunit family | Zinc finger FYVE domain-containing protein 26; Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis- recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair; Zinc fingers FYVE-type | 0.420 |
| AP5S1 | AP5B1 | ENSP00000481750 | ENSP00000454303 | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport; Armadillo-like helical domain containing | 0.993 |
| AP5S1 | AP5M1 | ENSP00000481750 | ENSP00000261558 | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair | AP-5 complex subunit mu-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-18395520, it may play a role in cell death; Belongs to the adaptor complexes medium subunit family | 0.989 |
| AP5S1 | AP5Z1 | ENSP00000481750 | ENSP00000297562 | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair; Armadillo-like helical domain containing | 0.991 |
| AP5S1 | SPG11 | ENSP00000481750 | ENSP00000261866 | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair | Spatacsin; May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport | 0.903 |
| AP5S1 | ZFYVE26 | ENSP00000481750 | ENSP00000251119 | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair | Zinc finger FYVE domain-containing protein 26; Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis- recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair; Zinc fingers FYVE-type | 0.895 |
| AP5Z1 | AP5B1 | ENSP00000297562 | ENSP00000454303 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair; Armadillo-like helical domain containing | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport; Armadillo-like helical domain containing | 0.990 |
| AP5Z1 | AP5M1 | ENSP00000297562 | ENSP00000261558 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair; Armadillo-like helical domain containing | AP-5 complex subunit mu-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-18395520, it may play a role in cell death; Belongs to the adaptor complexes medium subunit family | 0.982 |
