| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAM8 | ATP6V0C | ENSP00000453302 | ENSP00000329757 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | 0.900 |
| ADAM8 | CD59 | ENSP00000453302 | ENSP00000379191 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase; Blood group antigens | 0.900 |
| ADAM8 | CYSTM1 | ENSP00000453302 | ENSP00000261811 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1 | 0.901 |
| ADAM8 | LAMTOR2 | ENSP00000453302 | ENSP00000357288 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | Ragulator complex protein LAMTOR2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP ki [...] | 0.900 |
| ADAM8 | NRAS | ENSP00000453302 | ENSP00000358548 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
| ADAM8 | SLC2A3 | ENSP00000453302 | ENSP00000075120 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | Solute carrier family 2, facilitated glucose transporter member 3; Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily | 0.900 |
| ADAM8 | SNAP23 | ENSP00000453302 | ENSP00000249647 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family | 0.900 |
| ADAM8 | TMEM63A | ENSP00000453302 | ENSP00000355800 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel | 0.900 |
| ADAM8 | TSPAN14 | ENSP00000453302 | ENSP00000396270 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | Tetraspanin-14; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10- mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity); Belongs to the tetraspanin (TM4SF) family | 0.900 |
| ADAM8 | VAMP8 | ENSP00000453302 | ENSP00000263864 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] | 0.906 |
| ATP6V0C | ADAM8 | ENSP00000329757 | ENSP00000453302 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | 0.900 |
| ATP6V0C | CD59 | ENSP00000329757 | ENSP00000379191 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase; Blood group antigens | 0.900 |
| ATP6V0C | CYSTM1 | ENSP00000329757 | ENSP00000261811 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1 | 0.902 |
| ATP6V0C | LAMTOR2 | ENSP00000329757 | ENSP00000357288 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | Ragulator complex protein LAMTOR2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP ki [...] | 0.929 |
| ATP6V0C | NRAS | ENSP00000329757 | ENSP00000358548 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
| ATP6V0C | SLC2A3 | ENSP00000329757 | ENSP00000075120 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | Solute carrier family 2, facilitated glucose transporter member 3; Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily | 0.901 |
| ATP6V0C | SNAP23 | ENSP00000329757 | ENSP00000249647 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family | 0.923 |
| ATP6V0C | TMEM63A | ENSP00000329757 | ENSP00000355800 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel | 0.902 |
| ATP6V0C | TSPAN14 | ENSP00000329757 | ENSP00000396270 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | Tetraspanin-14; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10- mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity); Belongs to the tetraspanin (TM4SF) family | 0.900 |
| ATP6V0C | VAMP8 | ENSP00000329757 | ENSP00000263864 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] | 0.916 |
