node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CUL1 | CUL5 | ENSP00000326804 | ENSP00000376808 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the [...] | Cullin-5; Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulate [...] | 0.934 |
CUL1 | ENSG00000100926 | ENSP00000326804 | ENSP00000261789 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the [...] | Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family | 0.678 |
CUL1 | RBX1 | ENSP00000326804 | ENSP00000216225 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the [...] | E3 ubiquitin-protein ligase RBX1; E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription- coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets. The functional specificity of the E3 ubiquitin-protein li [...] | 0.999 |
CUL5 | CUL1 | ENSP00000376808 | ENSP00000326804 | Cullin-5; Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulate [...] | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the [...] | 0.934 |
CUL5 | ENSG00000100926 | ENSP00000376808 | ENSP00000261789 | Cullin-5; Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulate [...] | Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family | 0.678 |
CUL5 | RBX1 | ENSP00000376808 | ENSP00000216225 | Cullin-5; Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulate [...] | E3 ubiquitin-protein ligase RBX1; E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription- coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets. The functional specificity of the E3 ubiquitin-protein li [...] | 0.999 |
EBAG9 | ENSG00000100926 | ENSP00000337675 | ENSP00000261789 | Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family | 0.577 |
ENSG00000100926 | CUL1 | ENSP00000261789 | ENSP00000326804 | Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the [...] | 0.678 |
ENSG00000100926 | CUL5 | ENSP00000261789 | ENSP00000376808 | Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family | Cullin-5; Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulate [...] | 0.678 |
ENSG00000100926 | EBAG9 | ENSP00000261789 | ENSP00000337675 | Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family | Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | 0.577 |
ENSG00000100926 | EVA1A | ENSP00000261789 | ENSP00000233712 | Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family | Protein eva-1 homolog A; Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis | 0.584 |
ENSG00000100926 | FEN1 | ENSP00000261789 | ENSP00000305480 | Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family | Flap endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a [...] | 0.571 |
ENSG00000100926 | IPO4 | ENSP00000261789 | ENSP00000346453 | Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family | Importin-4; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | 0.685 |
ENSG00000100926 | NSA2 | ENSP00000261789 | ENSP00000483484 | Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family | Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity) | 0.796 |
ENSG00000100926 | RBX1 | ENSP00000261789 | ENSP00000216225 | Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family | E3 ubiquitin-protein ligase RBX1; E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription- coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets. The functional specificity of the E3 ubiquitin-protein li [...] | 0.678 |
ENSG00000100926 | TMEM174 | ENSP00000261789 | ENSP00000296776 | Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family | Transmembrane protein 174 | 0.805 |
ENSG00000100926 | TMEM74 | ENSP00000261789 | ENSP00000297459 | Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family | Transmembrane protein 74; Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction; Belongs to the TMEM74 family | 0.666 |
EVA1A | ENSG00000100926 | ENSP00000233712 | ENSP00000261789 | Protein eva-1 homolog A; Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis | Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family | 0.584 |
EVA1A | TMEM74 | ENSP00000233712 | ENSP00000297459 | Protein eva-1 homolog A; Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis | Transmembrane protein 74; Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction; Belongs to the TMEM74 family | 0.606 |
FEN1 | ENSG00000100926 | ENSP00000305480 | ENSP00000261789 | Flap endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a [...] | Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family | 0.571 |