• Version:
  • 11.0 [archived version]
STRINGSTRING
PLCL1 PLCL1 TEX9 TEX9 FAM185A FAM185A LHFPL3 LHFPL3 LRIT1 LRIT1 NOL4 NOL4 LHFPL4 LHFPL4 RNF103 RNF103 TSPAN31 TSPAN31 PAF1 PAF1 RBM42 RBM42
"NOL4" - Nucleolar protein 4 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NOL4Nucleolar protein 4 (638 aa)    
Predicted Functional Partners:
LHFPL4
LHFPL tetraspan subfamily member 4 (247 aa)
     
   
  0.705
PLCL1
Inactive phospholipase C-like protein 1; Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C; C2 domain containing phospholipases (1095 aa)
     
   
  0.679
PAF1
RNA polymerase II-associated factor 1 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and ’Ser-2’- and ’Ser-5’-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription [...] (531 aa)
           
  0.656
LHFPL3
LHFPL tetraspan subfamily member 3 (222 aa)
     
   
  0.610
FAM185A
Protein FAM185A; Family with sequence similarity 185 member A (392 aa)
           
  0.540
RBM42
RNA-binding protein 42; Binds (via the RRM domain) to the 3’-untranslated region (UTR) of CDKN1A mRNA; RNA binding motif containing (480 aa)
           
  0.533
LRIT1
Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction; Fibronectin type III domain containing (623 aa)
           
  0.521
TEX9
Testis-expressed protein 9; Testis expressed 9 (391 aa)
       
      0.513
RNF103
E3 ubiquitin-protein ligase RNF103; Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway; Ring finger proteins (685 aa)
           
  0.512
TSPAN31
Tetraspanin-31; Tetraspanin 31; Tetraspanins (210 aa)
           
  0.511
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (1%) [HD]