• Version:
  • 11.0 [archived version]
STRINGSTRING
SFXN3 SFXN3 RELL1 RELL1 CREG2 CREG2 SREK1IP1 SREK1IP1 HDHD1 HDHD1 FEZ2 FEZ2 ZNF430 ZNF430 SREK1 SREK1 TRIM28 TRIM28 C19orf44 C19orf44
"ZNF430" - Zinc finger protein 430 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF430Zinc finger protein 430; May be involved in transcriptional regulation; Zinc fingers C2H2-type (570 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
      
  0.928
C19orf44
Uncharacterized protein C19orf44; Chromosome 19 open reading frame 44 (657 aa)
            
  0.700
CREG2
Protein CREG2; Cellular repressor of E1A stimulated genes 2 (290 aa)
            
  0.497
SREK1IP1
Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival (155 aa)
            
  0.489
SFXN3
Sideroflexin-3; Potential iron transporter; Sideroflexins (325 aa)
            
  0.473
SREK1
Splicing regulatory glutamine/lysine-rich protein 1; Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity); RNA binding motif containing (624 aa)
      
   
  0.457
RELL1
RELT-like protein 1; RELT family; Belongs to the RELT family (271 aa)
            
  0.450
HDHD1
Pseudouridine-5’-phosphatase; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family (251 aa)
            
  0.440
FEZ2
Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation (380 aa)
            
  0.420
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]
STRING is part of the ELIXIR infrastructure: it is one of ELIXIR's Core Data Resources.  Learn more >