GPATCH2L protein (human) - STRING database

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GPATCH2L

G patch domain-containing protein 2-like; G-patch domain containing 2 like (482 aa)

Predicted Functional Partners:

IFT43

0.722

UHRF1BP1L

0.711

ZNF543

0.672

SVOPL

0.585

DAB2IP

0.577

VPS13C

0.548

FAM83A

0.544

NUDCD2

0.538

DHRS7B

0.538

PTPRH

0.525

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DAB2IP	GPATCH2L	ENSP00000259371	ENSP00000261530	Disabled homolog 2-interacting protein; Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon [...]	G patch domain-containing protein 2-like; G-patch domain containing 2 like	0.577
DAB2IP	IFT43	ENSP00000259371	ENSP00000238628	Disabled homolog 2-interacting protein; Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon [...]	Intraflagellar transport proteins	0.547
DHRS7B	GPATCH2L	ENSP00000378887	ENSP00000261530	Dehydrogenase/reductase SDR family member 7B; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily	G patch domain-containing protein 2-like; G-patch domain containing 2 like	0.538
FAM83A	GPATCH2L	ENSP00000428876	ENSP00000261530	Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation; Belongs to the FAM83 family	G patch domain-containing protein 2-like; G-patch domain containing 2 like	0.544
FAM83A	UHRF1BP1L	ENSP00000428876	ENSP00000279907	Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation; Belongs to the FAM83 family	UHRF1-binding protein 1-like; UHRF1 binding protein 1 like	0.586
FAM83A	VPS13C	ENSP00000428876	ENSP00000261517	Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation; Belongs to the FAM83 family	Vacuolar protein sorting-associated protein 13C; Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization	0.445
GPATCH2L	DAB2IP	ENSP00000261530	ENSP00000259371	G patch domain-containing protein 2-like; G-patch domain containing 2 like	Disabled homolog 2-interacting protein; Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon [...]	0.577
GPATCH2L	DHRS7B	ENSP00000261530	ENSP00000378887	G patch domain-containing protein 2-like; G-patch domain containing 2 like	Dehydrogenase/reductase SDR family member 7B; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily	0.538
GPATCH2L	FAM83A	ENSP00000261530	ENSP00000428876	G patch domain-containing protein 2-like; G-patch domain containing 2 like	Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation; Belongs to the FAM83 family	0.544
GPATCH2L	IFT43	ENSP00000261530	ENSP00000238628	G patch domain-containing protein 2-like; G-patch domain containing 2 like	Intraflagellar transport proteins	0.722
GPATCH2L	NUDCD2	ENSP00000261530	ENSP00000304854	G patch domain-containing protein 2-like; G-patch domain containing 2 like	NudC domain-containing protein 2; May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone; NudC family	0.538
GPATCH2L	PTPRH	ENSP00000261530	ENSP00000365528	G patch domain-containing protein 2-like; G-patch domain containing 2 like	Receptor-type tyrosine-protein phosphatase H; Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms- inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activati [...]	0.525
GPATCH2L	SVOPL	ENSP00000261530	ENSP00000405482	G patch domain-containing protein 2-like; G-patch domain containing 2 like	Putative transporter SVOPL; SVOP like; Belongs to the major facilitator superfamily	0.585
GPATCH2L	UHRF1BP1L	ENSP00000261530	ENSP00000279907	G patch domain-containing protein 2-like; G-patch domain containing 2 like	UHRF1-binding protein 1-like; UHRF1 binding protein 1 like	0.711
GPATCH2L	VPS13C	ENSP00000261530	ENSP00000261517	G patch domain-containing protein 2-like; G-patch domain containing 2 like	Vacuolar protein sorting-associated protein 13C; Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization	0.548
GPATCH2L	ZNF543	ENSP00000261530	ENSP00000322545	G patch domain-containing protein 2-like; G-patch domain containing 2 like	Zinc finger protein 543; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.672
IFT43	DAB2IP	ENSP00000238628	ENSP00000259371	Intraflagellar transport proteins	Disabled homolog 2-interacting protein; Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon [...]	0.547
IFT43	GPATCH2L	ENSP00000238628	ENSP00000261530	Intraflagellar transport proteins	G patch domain-containing protein 2-like; G-patch domain containing 2 like	0.722
NUDCD2	GPATCH2L	ENSP00000304854	ENSP00000261530	NudC domain-containing protein 2; May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone; NudC family	G patch domain-containing protein 2-like; G-patch domain containing 2 like	0.538
PTPRH	GPATCH2L	ENSP00000365528	ENSP00000261530	Receptor-type tyrosine-protein phosphatase H; Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms- inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activati [...]	G patch domain-containing protein 2-like; G-patch domain containing 2 like	0.525

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