node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP51A1 | FDFT1 | ENSP00000003100 | ENSP00000480828 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | 0.992 |
CYP51A1 | HMGCS1 | ENSP00000003100 | ENSP00000322706 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.986 |
CYP51A1 | HSD17B7 | ENSP00000003100 | ENSP00000254521 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | 3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Short chain dehydrogenase/reductase superfamily | 0.966 |
CYP51A1 | IDI1 | ENSP00000003100 | ENSP00000370748 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.975 |
CYP51A1 | LSS | ENSP00000003100 | ENSP00000380837 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency; Belongs to the terpene cyclase/mutase family | 0.999 |
CYP51A1 | MSMO1 | ENSP00000003100 | ENSP00000261507 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family | 0.997 |
CYP51A1 | NSDHL | ENSP00000003100 | ENSP00000359297 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis; Short chain dehydrogenase/reductase superfamily | 0.985 |
CYP51A1 | SC5D | ENSP00000003100 | ENSP00000264027 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Lathosterol oxidase; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol; Belongs to the sterol desaturase family | 0.989 |
CYP51A1 | SQLE | ENSP00000003100 | ENSP00000265896 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Squalene monooxygenase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway; Belongs to the squalene monooxygenase family | 0.993 |
CYP51A1 | TM7SF2 | ENSP00000003100 | ENSP00000279263 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Delta(14)-sterol reductase; Involved in the conversion of lanosterol to cholesterol | 0.990 |
FDFT1 | CYP51A1 | ENSP00000480828 | ENSP00000003100 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | 0.992 |
FDFT1 | HMGCS1 | ENSP00000480828 | ENSP00000322706 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.939 |
FDFT1 | HSD17B7 | ENSP00000480828 | ENSP00000254521 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | 3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Short chain dehydrogenase/reductase superfamily | 0.954 |
FDFT1 | IDI1 | ENSP00000480828 | ENSP00000370748 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.986 |
FDFT1 | LSS | ENSP00000480828 | ENSP00000380837 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency; Belongs to the terpene cyclase/mutase family | 0.992 |
FDFT1 | MSMO1 | ENSP00000480828 | ENSP00000261507 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family | 0.991 |
FDFT1 | NSDHL | ENSP00000480828 | ENSP00000359297 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis; Short chain dehydrogenase/reductase superfamily | 0.973 |
FDFT1 | SC5D | ENSP00000480828 | ENSP00000264027 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Lathosterol oxidase; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol; Belongs to the sterol desaturase family | 0.970 |
FDFT1 | SQLE | ENSP00000480828 | ENSP00000265896 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Squalene monooxygenase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway; Belongs to the squalene monooxygenase family | 0.997 |
FDFT1 | TM7SF2 | ENSP00000480828 | ENSP00000279263 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Delta(14)-sterol reductase; Involved in the conversion of lanosterol to cholesterol | 0.855 |