| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARMC1 | ARMC9 | ENSP00000276569 | ENSP00000484804 | Armadillo repeat containing 1 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | 0.727 |
| ARMC1 | RHBDD1 | ENSP00000276569 | ENSP00000375914 | Armadillo repeat containing 1 | Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...] | 0.747 |
| ARMC1 | SNAPC5 | ENSP00000276569 | ENSP00000319597 | Armadillo repeat containing 1 | snRNA-activating protein complex subunit 5; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box | 0.760 |
| ARMC1 | SNX24 | ENSP00000276569 | ENSP00000261369 | Armadillo repeat containing 1 | Sorting nexin-24; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.680 |
| ARMC9 | ARMC1 | ENSP00000484804 | ENSP00000276569 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | Armadillo repeat containing 1 | 0.727 |
| ARMC9 | RHBDD1 | ENSP00000484804 | ENSP00000375914 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...] | 0.720 |
| ARMC9 | SNAPC5 | ENSP00000484804 | ENSP00000319597 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | snRNA-activating protein complex subunit 5; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box | 0.762 |
| ARMC9 | SNX24 | ENSP00000484804 | ENSP00000261369 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | Sorting nexin-24; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.687 |
| C1orf111 | GAPVD1 | ENSP00000356912 | ENSP00000377664 | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | 0.823 |
| C1orf111 | SNX24 | ENSP00000356912 | ENSP00000261369 | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | Sorting nexin-24; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.686 |
| GAPVD1 | C1orf111 | ENSP00000377664 | ENSP00000356912 | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | 0.823 |
| GAPVD1 | SNX24 | ENSP00000377664 | ENSP00000261369 | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | Sorting nexin-24; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.866 |
| GAPVD1 | TSSK1B | ENSP00000377664 | ENSP00000375081 | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | Testis-specific serine/threonine-protein kinase 1; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates ’Ser-288’ of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body | 0.729 |
| ITFG2 | SNX24 | ENSP00000228799 | ENSP00000261369 | KICSTOR complex protein ITFG2; As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose | Sorting nexin-24; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.729 |
| RHBDD1 | ARMC1 | ENSP00000375914 | ENSP00000276569 | Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...] | Armadillo repeat containing 1 | 0.747 |
| RHBDD1 | ARMC9 | ENSP00000375914 | ENSP00000484804 | Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...] | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | 0.720 |
| RHBDD1 | SNAPC5 | ENSP00000375914 | ENSP00000319597 | Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...] | snRNA-activating protein complex subunit 5; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box | 0.727 |
| RHBDD1 | SNX24 | ENSP00000375914 | ENSP00000261369 | Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...] | Sorting nexin-24; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.693 |
| SNAPC5 | ARMC1 | ENSP00000319597 | ENSP00000276569 | snRNA-activating protein complex subunit 5; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box | Armadillo repeat containing 1 | 0.760 |
| SNAPC5 | ARMC9 | ENSP00000319597 | ENSP00000484804 | snRNA-activating protein complex subunit 5; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 | 0.762 |
