node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARSA | ASAH1 | ENSP00000216124 | ENSP00000371152 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | 0.621 |
ARSA | GAL3ST1 | ENSP00000216124 | ENSP00000385735 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Galactosylceramide sulfotransferase; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro); Belongs to the galactose-3-O-sulfotransferase family | 0.811 |
ARSA | GALC | ENSP00000216124 | ENSP00000261304 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon; Belongs to the glycosyl hydrolase 59 family | 0.965 |
ARSA | GLA | ENSP00000216124 | ENSP00000218516 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family | 0.946 |
ARSA | SMPD1 | ENSP00000216124 | ENSP00000340409 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol | 0.441 |
ASAH1 | ARSA | ENSP00000371152 | ENSP00000216124 | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | 0.621 |
ASAH1 | DEGS2 | ENSP00000371152 | ENSP00000307126 | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase; Fatty acid desaturases | 0.942 |
ASAH1 | GALC | ENSP00000371152 | ENSP00000261304 | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon; Belongs to the glycosyl hydrolase 59 family | 0.951 |
ASAH1 | GBA | ENSP00000371152 | ENSP00000314508 | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | Glucosylceramidase beta | 0.944 |
ASAH1 | SGMS1 | ENSP00000371152 | ENSP00000354829 | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | Phosphatidylcholine-ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell [...] | 0.952 |
ASAH1 | SGMS2 | ENSP00000371152 | ENSP00000378176 | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | Phosphatidylcholine-ceramide cholinephosphotransferase 2; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signa [...] | 0.955 |
ASAH1 | SMPD1 | ENSP00000371152 | ENSP00000340409 | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol | 0.945 |
ASAH1 | UGCG | ENSP00000371152 | ENSP00000363397 | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | Ceramide glucosyltransferase; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase"; Belongs to the glycosyltransferase 2 family | 0.965 |
DEGS2 | ASAH1 | ENSP00000307126 | ENSP00000371152 | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase; Fatty acid desaturases | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid | 0.942 |
DEGS2 | GALC | ENSP00000307126 | ENSP00000261304 | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase; Fatty acid desaturases | Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon; Belongs to the glycosyl hydrolase 59 family | 0.946 |
DEGS2 | GBA | ENSP00000307126 | ENSP00000314508 | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase; Fatty acid desaturases | Glucosylceramidase beta | 0.906 |
DEGS2 | SGMS1 | ENSP00000307126 | ENSP00000354829 | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase; Fatty acid desaturases | Phosphatidylcholine-ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell [...] | 0.976 |
DEGS2 | SGMS2 | ENSP00000307126 | ENSP00000378176 | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase; Fatty acid desaturases | Phosphatidylcholine-ceramide cholinephosphotransferase 2; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signa [...] | 0.963 |
DEGS2 | SMPD1 | ENSP00000307126 | ENSP00000340409 | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase; Fatty acid desaturases | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol | 0.781 |
DEGS2 | UGCG | ENSP00000307126 | ENSP00000363397 | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase; Fatty acid desaturases | Ceramide glucosyltransferase; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase"; Belongs to the glycosyltransferase 2 family | 0.955 |