| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C12orf4 | C18orf8 | ENSP00000261250 | ENSP00000269221 | Protein C12orf4; Plays a role in mast cell degranulation | Uncharacterized protein C18orf8; Chromosome 18 open reading frame 8; Belongs to the Mic1 family | 0.608 |
| C12orf4 | CLHC1 | ENSP00000261250 | ENSP00000384869 | Protein C12orf4; Plays a role in mast cell degranulation | Clathrin heavy chain linker domain containing 1 | 0.580 |
| C12orf4 | CPNE8 | ENSP00000261250 | ENSP00000329748 | Protein C12orf4; Plays a role in mast cell degranulation | Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Copines | 0.610 |
| C12orf4 | FAM160A2 | ENSP00000261250 | ENSP00000265978 | Protein C12orf4; Plays a role in mast cell degranulation | FTS and Hook-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex); Belongs to the UPF0518 family | 0.610 |
| C12orf4 | ITFG2 | ENSP00000261250 | ENSP00000228799 | Protein C12orf4; Plays a role in mast cell degranulation | KICSTOR complex protein ITFG2; As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose | 0.736 |
| C12orf4 | LPCAT3 | ENSP00000261250 | ENSP00000261407 | Protein C12orf4; Plays a role in mast cell degranulation | Lysophospholipid acyltransferase 5; Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3- phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero- 3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn- glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors com [...] | 0.571 |
| C12orf4 | PRICKLE1 | ENSP00000261250 | ENSP00000345064 | Protein C12orf4; Plays a role in mast cell degranulation | Prickle-like protein 1; Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor; LIM domain containing | 0.623 |
| C12orf4 | TBCK | ENSP00000261250 | ENSP00000273980 | Protein C12orf4; Plays a role in mast cell degranulation | TBC domain-containing protein kinase-like protein; Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization | 0.655 |
| C12orf4 | TMEM106C | ENSP00000261250 | ENSP00000400471 | Protein C12orf4; Plays a role in mast cell degranulation | Transmembrane protein 106C | 0.619 |
| C12orf4 | WDR93 | ENSP00000261250 | ENSP00000268130 | Protein C12orf4; Plays a role in mast cell degranulation | WD repeat-containing protein 93; WD repeat domain containing | 0.588 |
| C18orf8 | C12orf4 | ENSP00000269221 | ENSP00000261250 | Uncharacterized protein C18orf8; Chromosome 18 open reading frame 8; Belongs to the Mic1 family | Protein C12orf4; Plays a role in mast cell degranulation | 0.608 |
| C18orf8 | FAM160A2 | ENSP00000269221 | ENSP00000265978 | Uncharacterized protein C18orf8; Chromosome 18 open reading frame 8; Belongs to the Mic1 family | FTS and Hook-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex); Belongs to the UPF0518 family | 0.497 |
| C18orf8 | TBCK | ENSP00000269221 | ENSP00000273980 | Uncharacterized protein C18orf8; Chromosome 18 open reading frame 8; Belongs to the Mic1 family | TBC domain-containing protein kinase-like protein; Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization | 0.484 |
| CLHC1 | C12orf4 | ENSP00000384869 | ENSP00000261250 | Clathrin heavy chain linker domain containing 1 | Protein C12orf4; Plays a role in mast cell degranulation | 0.580 |
| CLHC1 | TBCK | ENSP00000384869 | ENSP00000273980 | Clathrin heavy chain linker domain containing 1 | TBC domain-containing protein kinase-like protein; Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization | 0.448 |
| CLHC1 | WDR93 | ENSP00000384869 | ENSP00000268130 | Clathrin heavy chain linker domain containing 1 | WD repeat-containing protein 93; WD repeat domain containing | 0.675 |
| CPNE8 | C12orf4 | ENSP00000329748 | ENSP00000261250 | Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Copines | Protein C12orf4; Plays a role in mast cell degranulation | 0.610 |
| CPNE8 | ITFG2 | ENSP00000329748 | ENSP00000228799 | Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Copines | KICSTOR complex protein ITFG2; As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose | 0.594 |
| CPNE8 | LPCAT3 | ENSP00000329748 | ENSP00000261407 | Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Copines | Lysophospholipid acyltransferase 5; Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3- phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero- 3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn- glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors com [...] | 0.467 |
| CPNE8 | PRICKLE1 | ENSP00000329748 | ENSP00000345064 | Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Copines | Prickle-like protein 1; Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor; LIM domain containing | 0.515 |
