• Version:
  • 11.0 [archived version]
STRINGSTRING
KLK15 KLK15 AMDHD1 AMDHD1 UROC1 UROC1 RRBP1 RRBP1 HAL HAL DCN DCN CARNS1 CARNS1 CNDP2 CNDP2 CNDP1 CNDP1 HDC HDC PAH PAH
"HAL" - Histidine ammonia-lyase in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HALHistidine ammonia-lyase (657 aa)    
Predicted Functional Partners:
UROC1
Urocanate hydratase 1 (736 aa)
 
  0.995
CARNS1
Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine (950 aa)
     
 
  0.967
HDC
Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine; Belongs to the group II decarboxylase family (662 aa)
     
 
  0.942
CNDP1
Carnosine dipeptidase 1; Belongs to the peptidase M20A family (507 aa)
   
 
  0.915
CNDP2
Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation. Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Catalyzes the production of N- lactoyl-amino acids from lactat [...] (475 aa)
   
 
  0.915
AMDHD1
Probable imidazolonepropionase; Amidohydrolase domain containing 1 (426 aa)
   
  0.911
PAH
Phenylalanine-4-hydroxylase; Phenylalanine hydroxylase (452 aa)
     
   
  0.704
KLK15
Kallikrein-15; Protease whose physiological substrate is not yet known; Kallikreins (256 aa)
     
   
  0.650
DCN
Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans (359 aa)
           
  0.647
RRBP1
Ribosome-binding protein 1; Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane (977 aa)
     
   
  0.646
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]