node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTBD16 | C15orf53 | ENSP00000260723 | ENSP00000325144 | BTB/POZ domain-containing protein 16; BTB domain containing 16 | Uncharacterized protein C15orf53; Chromosome 15 open reading frame 53 | 0.480 |
BTBD16 | CATSPER2 | ENSP00000260723 | ENSP00000371180 | BTB/POZ domain-containing protein 16; BTB domain containing 16 | Cation channel sperm-associated protein 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte; Belongs to the cation channel sperm-associated (TC 1.A.1.19) family | 0.527 |
BTBD16 | CATSPERG | ENSP00000260723 | ENSP00000386962 | BTB/POZ domain-containing protein 16; BTB domain containing 16 | Cation channel sperm-associated protein subunit gamma; Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization; Cation channels sperm associated | 0.608 |
BTBD16 | CPZ | ENSP00000260723 | ENSP00000354255 | BTB/POZ domain-containing protein 16; BTB domain containing 16 | Carboxypeptidase Z; Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing; M14 carboxypeptidases | 0.458 |
BTBD16 | DPY19L3 | ENSP00000260723 | ENSP00000344937 | BTB/POZ domain-containing protein 16; BTB domain containing 16 | Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family | 0.644 |
BTBD16 | NSMCE4A | ENSP00000260723 | ENSP00000358019 | BTB/POZ domain-containing protein 16; BTB domain containing 16 | Non-structural maintenance of chromosomes element 4 homolog A; Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies ( [...] | 0.511 |
BTBD16 | SLAMF1 | ENSP00000260723 | ENSP00000306190 | BTB/POZ domain-containing protein 16; BTB domain containing 16 | Signaling lymphocytic activation molecule; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal- transduction events in T-lymphocytes are different from thos [...] | 0.464 |
BTBD16 | SPATA18 | ENSP00000260723 | ENSP00000295213 | BTB/POZ domain-containing protein 16; BTB domain containing 16 | Mitochondria-eating protein; Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade [...] | 0.507 |
BTBD16 | SPATA22 | ENSP00000260723 | ENSP00000459580 | BTB/POZ domain-containing protein 16; BTB domain containing 16 | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | 0.550 |
BTBD16 | ZBTB16 | ENSP00000260723 | ENSP00000338157 | BTB/POZ domain-containing protein 16; BTB domain containing 16 | Zinc finger and BTB domain-containing protein 16; Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.468 |
C15orf53 | BTBD16 | ENSP00000325144 | ENSP00000260723 | Uncharacterized protein C15orf53; Chromosome 15 open reading frame 53 | BTB/POZ domain-containing protein 16; BTB domain containing 16 | 0.480 |
C15orf53 | DPY19L3 | ENSP00000325144 | ENSP00000344937 | Uncharacterized protein C15orf53; Chromosome 15 open reading frame 53 | Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family | 0.470 |
CATSPER2 | BTBD16 | ENSP00000371180 | ENSP00000260723 | Cation channel sperm-associated protein 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte; Belongs to the cation channel sperm-associated (TC 1.A.1.19) family | BTB/POZ domain-containing protein 16; BTB domain containing 16 | 0.527 |
CATSPER2 | CATSPERG | ENSP00000371180 | ENSP00000386962 | Cation channel sperm-associated protein 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte; Belongs to the cation channel sperm-associated (TC 1.A.1.19) family | Cation channel sperm-associated protein subunit gamma; Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization; Cation channels sperm associated | 0.968 |
CATSPER2 | SPATA22 | ENSP00000371180 | ENSP00000459580 | Cation channel sperm-associated protein 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte; Belongs to the cation channel sperm-associated (TC 1.A.1.19) family | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | 0.415 |
CATSPERG | BTBD16 | ENSP00000386962 | ENSP00000260723 | Cation channel sperm-associated protein subunit gamma; Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization; Cation channels sperm associated | BTB/POZ domain-containing protein 16; BTB domain containing 16 | 0.608 |
CATSPERG | CATSPER2 | ENSP00000386962 | ENSP00000371180 | Cation channel sperm-associated protein subunit gamma; Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization; Cation channels sperm associated | Cation channel sperm-associated protein 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte; Belongs to the cation channel sperm-associated (TC 1.A.1.19) family | 0.968 |
CATSPERG | SPATA18 | ENSP00000386962 | ENSP00000295213 | Cation channel sperm-associated protein subunit gamma; Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization; Cation channels sperm associated | Mitochondria-eating protein; Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade [...] | 0.462 |
CATSPERG | SPATA22 | ENSP00000386962 | ENSP00000459580 | Cation channel sperm-associated protein subunit gamma; Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization; Cation channels sperm associated | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | 0.499 |
CPZ | BTBD16 | ENSP00000354255 | ENSP00000260723 | Carboxypeptidase Z; Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing; M14 carboxypeptidases | BTB/POZ domain-containing protein 16; BTB domain containing 16 | 0.458 |