FAM8A1 protein (human) - STRING database

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FAM8A1

Protein FAM8A1; Family with sequence similarity 8 member A1 (413 aa)

Predicted Functional Partners:

SYVN1

0.960

ERLEC1

0.933

SEL1L

0.930

OS9

0.930

SLC51A

0.653

INSC

0.644

EMC8

0.626

UBAC2

0.602

MBOAT1

0.596

EMC7

0.573

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EMC7	EMC8	ENSP00000256545	ENSP00000253457	ER membrane protein complex subunit 7	ER membrane protein complex subunit 8	0.996
EMC7	FAM8A1	ENSP00000256545	ENSP00000259963	ER membrane protein complex subunit 7	Protein FAM8A1; Family with sequence similarity 8 member A1	0.573
EMC7	UBAC2	ENSP00000256545	ENSP00000383911	ER membrane protein complex subunit 7	Ubiquitin-associated domain-containing protein 2; Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets; Rhomboid family	0.531
EMC8	EMC7	ENSP00000253457	ENSP00000256545	ER membrane protein complex subunit 8	ER membrane protein complex subunit 7	0.996
EMC8	ERLEC1	ENSP00000253457	ENSP00000185150	ER membrane protein complex subunit 8	Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins; MRH domain containing	0.457
EMC8	FAM8A1	ENSP00000253457	ENSP00000259963	ER membrane protein complex subunit 8	Protein FAM8A1; Family with sequence similarity 8 member A1	0.626
EMC8	UBAC2	ENSP00000253457	ENSP00000383911	ER membrane protein complex subunit 8	Ubiquitin-associated domain-containing protein 2; Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets; Rhomboid family	0.638
ERLEC1	EMC8	ENSP00000185150	ENSP00000253457	Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins; MRH domain containing	ER membrane protein complex subunit 8	0.457
ERLEC1	FAM8A1	ENSP00000185150	ENSP00000259963	Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins; MRH domain containing	Protein FAM8A1; Family with sequence similarity 8 member A1	0.933
ERLEC1	OS9	ENSP00000185150	ENSP00000318165	Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins; MRH domain containing	Protein OS-9; Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4; MRH domain containing	0.990
ERLEC1	SEL1L	ENSP00000185150	ENSP00000337053	Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins; MRH domain containing	Protein sel-1 homolog 1; Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling	0.999
ERLEC1	SYVN1	ENSP00000185150	ENSP00000366395	Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins; MRH domain containing	E3 ubiquitin-protein ligase synoviolin; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from [...]	0.998
FAM8A1	EMC7	ENSP00000259963	ENSP00000256545	Protein FAM8A1; Family with sequence similarity 8 member A1	ER membrane protein complex subunit 7	0.573
FAM8A1	EMC8	ENSP00000259963	ENSP00000253457	Protein FAM8A1; Family with sequence similarity 8 member A1	ER membrane protein complex subunit 8	0.626
FAM8A1	ERLEC1	ENSP00000259963	ENSP00000185150	Protein FAM8A1; Family with sequence similarity 8 member A1	Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins; MRH domain containing	0.933
FAM8A1	INSC	ENSP00000259963	ENSP00000368872	Protein FAM8A1; Family with sequence similarity 8 member A1	Protein inscuteable homolog; May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity); Armadillo-like helical domain containing	0.644
FAM8A1	MBOAT1	ENSP00000259963	ENSP00000324944	Protein FAM8A1; Family with sequence similarity 8 member A1	Lysophospholipid acyltransferase 1; Acyltransferase which mediates the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L- serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3- phospho-L-serine or PS) (LPSAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle; Membrane bound O-acyltransferases	0.596
FAM8A1	OS9	ENSP00000259963	ENSP00000318165	Protein FAM8A1; Family with sequence similarity 8 member A1	Protein OS-9; Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4; MRH domain containing	0.930
FAM8A1	SEL1L	ENSP00000259963	ENSP00000337053	Protein FAM8A1; Family with sequence similarity 8 member A1	Protein sel-1 homolog 1; Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling	0.930
FAM8A1	SLC51A	ENSP00000259963	ENSP00000296327	Protein FAM8A1; Family with sequence similarity 8 member A1	Organic solute transporter subunit alpha; Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids; Solute carriers	0.653

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