| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CNGB1 | NRM | ENSP00000251102 | ENSP00000259953 | Cyclic nucleotide-gated cation channel beta-1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | Nurim | 0.799 |
| CNGB3 | NRM | ENSP00000316605 | ENSP00000259953 | Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked ele [...] | Nurim | 0.734 |
| GTF2H4 | NRM | ENSP00000259895 | ENSP00000259953 | General transcription factor IIH subunit 4; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II; General transcription factors | Nurim | 0.679 |
| GTF2H4 | RPP21 | ENSP00000259895 | ENSP00000409799 | General transcription factor IIH subunit 4; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II; General transcription factors | Ribonuclease P protein subunit p21; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends; Belongs to the eukaryotic/archaeal RNase P protein component 4 family | 0.659 |
| GTF2H4 | TCF19 | ENSP00000259895 | ENSP00000365433 | General transcription factor IIH subunit 4; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II; General transcription factors | Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression; PHD finger proteins | 0.667 |
| LBR | NRM | ENSP00000339883 | ENSP00000259953 | Lamin-B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane; Tudor domain containing | Nurim | 0.738 |
| LBR | SUN2 | ENSP00000339883 | ENSP00000385616 | Lamin-B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane; Tudor domain containing | SUN domain-containing protein 2; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin- associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin- depe [...] | 0.765 |
| MDN1 | NRM | ENSP00000358400 | ENSP00000259953 | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre- 60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to [...] | Nurim | 0.711 |
| NRM | CNGB1 | ENSP00000259953 | ENSP00000251102 | Nurim | Cyclic nucleotide-gated cation channel beta-1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | 0.799 |
| NRM | CNGB3 | ENSP00000259953 | ENSP00000316605 | Nurim | Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked ele [...] | 0.734 |
| NRM | GTF2H4 | ENSP00000259953 | ENSP00000259895 | Nurim | General transcription factor IIH subunit 4; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II; General transcription factors | 0.679 |
| NRM | LBR | ENSP00000259953 | ENSP00000339883 | Nurim | Lamin-B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane; Tudor domain containing | 0.738 |
| NRM | MDN1 | ENSP00000259953 | ENSP00000358400 | Nurim | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre- 60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to [...] | 0.711 |
| NRM | RPP21 | ENSP00000259953 | ENSP00000409799 | Nurim | Ribonuclease P protein subunit p21; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends; Belongs to the eukaryotic/archaeal RNase P protein component 4 family | 0.668 |
| NRM | SMTNL1 | ENSP00000259953 | ENSP00000432651 | Nurim | Smoothelin-like protein 1; Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity) | 0.711 |
| NRM | SUN2 | ENSP00000259953 | ENSP00000385616 | Nurim | SUN domain-containing protein 2; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin- associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin- depe [...] | 0.724 |
| NRM | TCF19 | ENSP00000259953 | ENSP00000365433 | Nurim | Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression; PHD finger proteins | 0.665 |
| NRM | VWA8 | ENSP00000259953 | ENSP00000368612 | Nurim | Von Willebrand factor A domain-containing protein 8; Exhibits ATPase activity in vitro | 0.711 |
| RPP21 | GTF2H4 | ENSP00000409799 | ENSP00000259895 | Ribonuclease P protein subunit p21; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends; Belongs to the eukaryotic/archaeal RNase P protein component 4 family | General transcription factor IIH subunit 4; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II; General transcription factors | 0.659 |
| RPP21 | NRM | ENSP00000409799 | ENSP00000259953 | Ribonuclease P protein subunit p21; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends; Belongs to the eukaryotic/archaeal RNase P protein component 4 family | Nurim | 0.668 |
