| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C6orf15 | ERC2 | ENSP00000259870 | ENSP00000288221 | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | ERC protein 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ | 0.650 |
| C6orf15 | HLA-C | ENSP00000259870 | ENSP00000365402 | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | HLA class I histocompatibility antigen, Cw-7 alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family | 0.743 |
| C6orf15 | KLK4 | ENSP00000259870 | ENSP00000326159 | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity); Kallikreins | 0.702 |
| C6orf15 | MAPK8IP2 | ENSP00000259870 | ENSP00000330572 | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | C-Jun-amino-terminal kinase-interacting protein 2; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity) | 0.578 |
| C6orf15 | MOG | ENSP00000259870 | ENSP00000366095 | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | Myelin-oligodendrocyte glycoprotein; Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication; Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.630 |
| C6orf15 | PRSS3 | ENSP00000259870 | ENSP00000354280 | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | Trypsin-3; Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family | 0.921 |
| C6orf15 | RAD1 | ENSP00000259870 | ENSP00000371469 | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | Cell cycle checkpoint protein RAD1; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3’-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavag [...] | 0.586 |
| C6orf15 | SGPL1 | ENSP00000259870 | ENSP00000362298 | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis; Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily | 0.664 |
| C6orf15 | SP140 | ENSP00000259870 | ENSP00000375899 | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | Nuclear body protein SP140; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails; Bromodomain containing | 0.570 |
| C6orf15 | TG | ENSP00000259870 | ENSP00000220616 | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | Thyroglobulin; Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3); Belongs to the type-B carboxylesterase/lipase family | 0.710 |
| ERC2 | C6orf15 | ENSP00000288221 | ENSP00000259870 | ERC protein 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | 0.650 |
| HLA-C | C6orf15 | ENSP00000365402 | ENSP00000259870 | HLA class I histocompatibility antigen, Cw-7 alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | 0.743 |
| KLK4 | C6orf15 | ENSP00000326159 | ENSP00000259870 | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity); Kallikreins | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | 0.702 |
| MAPK8IP2 | C6orf15 | ENSP00000330572 | ENSP00000259870 | C-Jun-amino-terminal kinase-interacting protein 2; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity) | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | 0.578 |
| MOG | C6orf15 | ENSP00000366095 | ENSP00000259870 | Myelin-oligodendrocyte glycoprotein; Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication; Belongs to the immunoglobulin superfamily. BTN/MOG family | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | 0.630 |
| MOG | PRSS3 | ENSP00000366095 | ENSP00000354280 | Myelin-oligodendrocyte glycoprotein; Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication; Belongs to the immunoglobulin superfamily. BTN/MOG family | Trypsin-3; Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family | 0.580 |
| PRSS3 | C6orf15 | ENSP00000354280 | ENSP00000259870 | Trypsin-3; Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | 0.921 |
| PRSS3 | MOG | ENSP00000354280 | ENSP00000366095 | Trypsin-3; Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family | Myelin-oligodendrocyte glycoprotein; Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication; Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.580 |
| PRSS3 | TG | ENSP00000354280 | ENSP00000220616 | Trypsin-3; Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family | Thyroglobulin; Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3); Belongs to the type-B carboxylesterase/lipase family | 0.710 |
| RAD1 | C6orf15 | ENSP00000371469 | ENSP00000259870 | Cell cycle checkpoint protein RAD1; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3’-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavag [...] | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 | 0.586 |
