TINAG protein (human) - STRING database

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TINAG

Tubulointerstitial nephritis antigen; Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein (476 aa)

Predicted Functional Partners:

TINF2

0.743

LRRC1

0.723

CCDC81

0.707

SMAP1

0.673

CPO

0.661

TNKS

0.641

PHF3

0.638

PRDX3

0.628

FST

0.624

PTP4A1

0.614

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC81	TINAG	ENSP00000415528	ENSP00000259782	Coiled-coil domain containing 81	Tubulointerstitial nephritis antigen; Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein	0.707
CPO	TINAG	ENSP00000272852	ENSP00000259782	Carboxypeptidase O; Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C- terminal hydrophobic amino acids, with a preference for small residues over large residues; M14 carboxypeptidases	Tubulointerstitial nephritis antigen; Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein	0.661
FST	TINAG	ENSP00000256759	ENSP00000259782	Follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH)	Tubulointerstitial nephritis antigen; Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein	0.624
LRRC1	PHF3	ENSP00000359925	ENSP00000262043	Leucine-rich repeat-containing protein 1; Leucine rich repeat containing 1	PHD finger protein 3	0.588
LRRC1	PRDX3	ENSP00000359925	ENSP00000298510	Leucine-rich repeat-containing protein 1; Leucine rich repeat containing 1	Thioredoxin-dependent peroxide reductase, mitochondrial; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol; Peroxiredoxins	0.622
LRRC1	PTP4A1	ENSP00000359925	ENSP00000359685	Leucine-rich repeat-containing protein 1; Leucine rich repeat containing 1	Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis	0.598
LRRC1	SMAP1	ENSP00000359925	ENSP00000359484	Leucine-rich repeat-containing protein 1; Leucine rich repeat containing 1	Stromal membrane-associated protein 1; GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity); ArfGAPs	0.758
LRRC1	TINAG	ENSP00000359925	ENSP00000259782	Leucine-rich repeat-containing protein 1; Leucine rich repeat containing 1	Tubulointerstitial nephritis antigen; Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein	0.723
PHF3	LRRC1	ENSP00000262043	ENSP00000359925	PHD finger protein 3	Leucine-rich repeat-containing protein 1; Leucine rich repeat containing 1	0.588
PHF3	PTP4A1	ENSP00000262043	ENSP00000359685	PHD finger protein 3	Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis	0.718
PHF3	TINAG	ENSP00000262043	ENSP00000259782	PHD finger protein 3	Tubulointerstitial nephritis antigen; Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein	0.638
PRDX3	LRRC1	ENSP00000298510	ENSP00000359925	Thioredoxin-dependent peroxide reductase, mitochondrial; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol; Peroxiredoxins	Leucine-rich repeat-containing protein 1; Leucine rich repeat containing 1	0.622
PRDX3	TINAG	ENSP00000298510	ENSP00000259782	Thioredoxin-dependent peroxide reductase, mitochondrial; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol; Peroxiredoxins	Tubulointerstitial nephritis antigen; Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein	0.628
PTP4A1	LRRC1	ENSP00000359685	ENSP00000359925	Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis	Leucine-rich repeat-containing protein 1; Leucine rich repeat containing 1	0.598
PTP4A1	PHF3	ENSP00000359685	ENSP00000262043	Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis	PHD finger protein 3	0.718
PTP4A1	TINAG	ENSP00000359685	ENSP00000259782	Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis	Tubulointerstitial nephritis antigen; Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein	0.614
SMAP1	LRRC1	ENSP00000359484	ENSP00000359925	Stromal membrane-associated protein 1; GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity); ArfGAPs	Leucine-rich repeat-containing protein 1; Leucine rich repeat containing 1	0.758
SMAP1	TINAG	ENSP00000359484	ENSP00000259782	Stromal membrane-associated protein 1; GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity); ArfGAPs	Tubulointerstitial nephritis antigen; Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein	0.673
TINAG	CCDC81	ENSP00000259782	ENSP00000415528	Tubulointerstitial nephritis antigen; Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein	Coiled-coil domain containing 81	0.707
TINAG	CPO	ENSP00000259782	ENSP00000272852	Tubulointerstitial nephritis antigen; Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein	Carboxypeptidase O; Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C- terminal hydrophobic amino acids, with a preference for small residues over large residues; M14 carboxypeptidases	0.661

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