node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBWD1 | CBWD2 | ENSP00000366617 | ENSP00000259199 | COBW domain containing 1 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | 0.586 |
CBWD1 | CBWD7 | ENSP00000366617 | ENSP00000366608 | COBW domain containing 1 | COBW domain-containing protein 6; COBW domain containing 7; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | 0.554 |
CBWD1 | METAP1 | ENSP00000366617 | ENSP00000296411 | COBW domain containing 1 | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily | 0.473 |
CBWD1 | TCERG1 | ENSP00000366617 | ENSP00000296702 | COBW domain containing 1 | Transcription elongation regulator 1; Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter | 0.665 |
CBWD2 | CBWD1 | ENSP00000259199 | ENSP00000366617 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | COBW domain containing 1 | 0.586 |
CBWD2 | CBWD7 | ENSP00000259199 | ENSP00000366608 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | COBW domain-containing protein 6; COBW domain containing 7; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | 0.873 |
CBWD2 | EGLN1 | ENSP00000259199 | ENSP00000355601 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | Egl nine homolog 1; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is [...] | 0.807 |
CBWD2 | HSPA12A | ENSP00000259199 | ENSP00000358211 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | Heat shock protein family A member 12A | 0.694 |
CBWD2 | METAP1 | ENSP00000259199 | ENSP00000296411 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily | 0.866 |
CBWD2 | NEK4 | ENSP00000259199 | ENSP00000233027 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | Serine/threonine-protein kinase Nek4; Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage | 0.531 |
CBWD2 | RABL2A | ENSP00000259199 | ENSP00000376872 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | Rab-like protein 2A; Plays an essential role in male fertility, sperm intra- flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail; RAB like GTPases | 0.561 |
CBWD2 | SFTA2 | ENSP00000259199 | ENSP00000351989 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | Surfactant-associated protein 2; Putative surfactant protein | 0.692 |
CBWD2 | TCERG1 | ENSP00000259199 | ENSP00000296702 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | Transcription elongation regulator 1; Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter | 0.855 |
CBWD2 | WASH2P | ENSP00000259199 | ENSP00000485442 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | WAS protein family homolog 2; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Its assembly in the WASH core complex seems to inhibit its NPF activity and via WASHC2 is required for its membrane targeting. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and invo [...] | 0.726 |
CBWD7 | CBWD1 | ENSP00000366608 | ENSP00000366617 | COBW domain-containing protein 6; COBW domain containing 7; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | COBW domain containing 1 | 0.554 |
CBWD7 | CBWD2 | ENSP00000366608 | ENSP00000259199 | COBW domain-containing protein 6; COBW domain containing 7; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | 0.873 |
EGLN1 | CBWD2 | ENSP00000355601 | ENSP00000259199 | Egl nine homolog 1; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is [...] | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | 0.807 |
HSPA12A | CBWD2 | ENSP00000358211 | ENSP00000259199 | Heat shock protein family A member 12A | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | 0.694 |
METAP1 | CBWD1 | ENSP00000296411 | ENSP00000366617 | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily | COBW domain containing 1 | 0.473 |
METAP1 | CBWD2 | ENSP00000296411 | ENSP00000259199 | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily | 0.866 |