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  • 11.0 [archived version]
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HEATR3 HEATR3 TMEM88B TMEM88B TMEM240 TMEM240 CFAP44 CFAP44 MAD2L1BP MAD2L1BP ABHD17C ABHD17C COMMD10 COMMD10 RGSL1 RGSL1 STX12 STX12 CACUL1 CACUL1 MSL2 MSL2
"ABHD17C" - Protein ABHD17C in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ABHD17CProtein ABHD17C; Abhydrolase domain containing 17C (329 aa)    
Predicted Functional Partners:
CACUL1
CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition (369 aa)
     
   
  0.577
RGSL1
Regulator of G protein signaling like 1 (1076 aa)
           
  0.576
HEATR3
HEAT repeat-containing protein 3; Armadillo-like helical domain containing (680 aa)
           
  0.576
MAD2L1BP
MAD2L1-binding protein; May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex; Belongs to the MAD2L1BP family (306 aa)
           
  0.571
TMEM240
Transmembrane protein 240; Belongs to the TMEM240 family (173 aa)
           
  0.569
COMMD10
COMM domain-containing protein 10; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B (202 aa)
           
  0.569
TMEM88B
Transmembrane protein 88B (163 aa)
           
  0.568
CFAP44
Cilia and flagella associated protein 44; Belongs to the CFAP44 family (1854 aa)
     
   
  0.539
MSL2
E3 ubiquitin-protein ligase MSL2; Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at ’Lys-35’ (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at ’Lys-4’ (H3K4me) and ’Lys-79’ (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (577 aa)
     
   
  0.531
STX12
Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity); Belongs to the syntaxin family (276 aa)
     
   
  0.497
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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