node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD17C | CACUL1 | ENSP00000258884 | ENSP00000358147 | Protein ABHD17C; Abhydrolase domain containing 17C | CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition | 0.577 |
ABHD17C | CFAP44 | ENSP00000258884 | ENSP00000377428 | Protein ABHD17C; Abhydrolase domain containing 17C | Cilia and flagella associated protein 44; Belongs to the CFAP44 family | 0.539 |
ABHD17C | COMMD10 | ENSP00000258884 | ENSP00000274458 | Protein ABHD17C; Abhydrolase domain containing 17C | COMM domain-containing protein 10; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B | 0.569 |
ABHD17C | HEATR3 | ENSP00000258884 | ENSP00000299192 | Protein ABHD17C; Abhydrolase domain containing 17C | HEAT repeat-containing protein 3; Armadillo-like helical domain containing | 0.576 |
ABHD17C | MAD2L1BP | ENSP00000258884 | ENSP00000410818 | Protein ABHD17C; Abhydrolase domain containing 17C | MAD2L1-binding protein; May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex; Belongs to the MAD2L1BP family | 0.571 |
ABHD17C | MSL2 | ENSP00000258884 | ENSP00000311827 | Protein ABHD17C; Abhydrolase domain containing 17C | E3 ubiquitin-protein ligase MSL2; Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at ’Lys-35’ (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at ’Lys-4’ (H3K4me) and ’Lys-79’ (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 | 0.531 |
ABHD17C | RGSL1 | ENSP00000258884 | ENSP00000457748 | Protein ABHD17C; Abhydrolase domain containing 17C | Regulator of G protein signaling like 1 | 0.576 |
ABHD17C | STX12 | ENSP00000258884 | ENSP00000363054 | Protein ABHD17C; Abhydrolase domain containing 17C | Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity); Belongs to the syntaxin family | 0.497 |
ABHD17C | TMEM240 | ENSP00000258884 | ENSP00000368007 | Protein ABHD17C; Abhydrolase domain containing 17C | Transmembrane protein 240; Belongs to the TMEM240 family | 0.569 |
ABHD17C | TMEM88B | ENSP00000258884 | ENSP00000455099 | Protein ABHD17C; Abhydrolase domain containing 17C | Transmembrane protein 88B | 0.568 |
CACUL1 | ABHD17C | ENSP00000358147 | ENSP00000258884 | CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition | Protein ABHD17C; Abhydrolase domain containing 17C | 0.577 |
CACUL1 | COMMD10 | ENSP00000358147 | ENSP00000274458 | CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition | COMM domain-containing protein 10; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B | 0.523 |
CACUL1 | MAD2L1BP | ENSP00000358147 | ENSP00000410818 | CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition | MAD2L1-binding protein; May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex; Belongs to the MAD2L1BP family | 0.513 |
CACUL1 | RGSL1 | ENSP00000358147 | ENSP00000457748 | CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition | Regulator of G protein signaling like 1 | 0.521 |
CACUL1 | STX12 | ENSP00000358147 | ENSP00000363054 | CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition | Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity); Belongs to the syntaxin family | 0.427 |
CACUL1 | TMEM240 | ENSP00000358147 | ENSP00000368007 | CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition | Transmembrane protein 240; Belongs to the TMEM240 family | 0.497 |
CACUL1 | TMEM88B | ENSP00000358147 | ENSP00000455099 | CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition | Transmembrane protein 88B | 0.493 |
CFAP44 | ABHD17C | ENSP00000377428 | ENSP00000258884 | Cilia and flagella associated protein 44; Belongs to the CFAP44 family | Protein ABHD17C; Abhydrolase domain containing 17C | 0.539 |
COMMD10 | ABHD17C | ENSP00000274458 | ENSP00000258884 | COMM domain-containing protein 10; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B | Protein ABHD17C; Abhydrolase domain containing 17C | 0.569 |
COMMD10 | CACUL1 | ENSP00000274458 | ENSP00000358147 | COMM domain-containing protein 10; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B | CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition | 0.523 |