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  • 11.0 [archived version]
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ZNF467 ZNF467 IQCE IQCE TTYH3 TTYH3 BEST2 BEST2 CLCC1 CLCC1 BEST4 BEST4 BEST1 BEST1 GLRB GLRB ANO1 ANO1 ANO2 ANO2 BEST3 BEST3
"TTYH3" - Protein tweety homolog 3 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
TTYH3Protein tweety homolog 3; Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction; Belongs to the tweety family (523 aa)    
Predicted Functional Partners:
BEST2
Bestrophin-2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Bestrophins (509 aa)
         
  0.737
ANO1
Anoctamin-1; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development; Belongs to the anoctamin family (986 aa)
     
 
  0.705
BEST4
Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Bestrophins (473 aa)
         
  0.701
BEST3
Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family (668 aa)
         
  0.693
BEST1
Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate; Bestrophins (604 aa)
         
  0.673
ANO2
Anoctamin-2; Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina; Anoctamins (999 aa)
     
 
  0.671
CLCC1
Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel; Tetraspan junctional complex superfamily (551 aa)
         
  0.661
ZNF467
Zinc finger protein 467; Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5’-CTTCTGGGAAGA-3’ of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity); Zinc fingers C2H2-type (595 aa)
     
   
  0.653
IQCE
IQ domain-containing protein E; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (702 aa)
 
 
   
  0.648
GLRB
Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (497 aa)
         
  0.612
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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