| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AAAS | GLE1 | ENSP00000209873 | ENSP00000308622 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | 0.969 |
| AAAS | NUP107 | ENSP00000209873 | ENSP00000229179 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC; Belongs to the nucleoporin Nup84/Nup107 family | 0.987 |
| AAAS | NUP153 | ENSP00000209873 | ENSP00000444029 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. [...] | 0.971 |
| AAAS | NUP214 | ENSP00000209873 | ENSP00000352400 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nuclear pore complex protein Nup214; May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex; Nucleoporins | 0.951 |
| AAAS | NUP37 | ENSP00000209873 | ENSP00000448054 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nucleoporin Nup37; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation; Nucleoporins | 0.975 |
| AAAS | NUP54 | ENSP00000209873 | ENSP00000264883 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nucleoporin p54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane; Nucleoporins | 0.945 |
| AAAS | NUP88 | ENSP00000209873 | ENSP00000458954 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nuclear pore complex protein Nup88; Essential component of nuclear pore complex; Nucleoporins | 0.951 |
| AAAS | NUP93 | ENSP00000209873 | ENSP00000310668 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling | 0.955 |
| AAAS | NUPL2 | ENSP00000209873 | ENSP00000258742 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nucleoporin-like protein 2; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope | 0.949 |
| AAAS | RANBP2 | ENSP00000209873 | ENSP00000283195 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore comple [...] | 0.949 |
| GLE1 | AAAS | ENSP00000308622 | ENSP00000209873 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | 0.969 |
| GLE1 | NUP107 | ENSP00000308622 | ENSP00000229179 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC; Belongs to the nucleoporin Nup84/Nup107 family | 0.990 |
| GLE1 | NUP153 | ENSP00000308622 | ENSP00000444029 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. [...] | 0.988 |
| GLE1 | NUP214 | ENSP00000308622 | ENSP00000352400 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nuclear pore complex protein Nup214; May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex; Nucleoporins | 0.996 |
| GLE1 | NUP37 | ENSP00000308622 | ENSP00000448054 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nucleoporin Nup37; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation; Nucleoporins | 0.945 |
| GLE1 | NUP54 | ENSP00000308622 | ENSP00000264883 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nucleoporin p54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane; Nucleoporins | 0.964 |
| GLE1 | NUP88 | ENSP00000308622 | ENSP00000458954 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nuclear pore complex protein Nup88; Essential component of nuclear pore complex; Nucleoporins | 0.981 |
| GLE1 | NUP93 | ENSP00000308622 | ENSP00000310668 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling | 0.968 |
| GLE1 | NUPL2 | ENSP00000308622 | ENSP00000258742 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nucleoporin-like protein 2; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope | 0.996 |
| GLE1 | RANBP2 | ENSP00000308622 | ENSP00000283195 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore comple [...] | 0.960 |
