ALDH1L2 protein (human) - STRING database

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ALDH1L2

Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family (923 aa)

Predicted Functional Partners:

SHMT2

0.969

MTHFD2

0.965

SHMT1

0.964

MTHFD1

0.961

MTHFD2L

0.944

FTCD

0.936

AMT

0.933

DHFR

0.931

MTR

0.929

GART

0.916

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1L2	AMT	ENSP00000258494	ENSP00000273588	Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	0.933
ALDH1L2	DHFR	ENSP00000258494	ENSP00000396308	Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2	0.931
ALDH1L2	FTCD	ENSP00000258494	ENSP00000291670	Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family	Formimidoyltransferase-cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family	0.936
ALDH1L2	GART	ENSP00000258494	ENSP00000371253	Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family	Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family	0.916
ALDH1L2	MTHFD1	ENSP00000258494	ENSP00000216605	Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family	C-1-tetrahydrofolate synthase, cytoplasmic; Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family	0.961
ALDH1L2	MTHFD2	ENSP00000258494	ENSP00000377617	Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency; Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family	0.965
ALDH1L2	MTHFD2L	ENSP00000258494	ENSP00000379108	Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family	Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; Methylenetetrahydrofolate dehydrogenase 2 like	0.944
ALDH1L2	MTR	ENSP00000258494	ENSP00000355536	Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity); Belongs to the vitamin-B12 dependent methionine synthase family	0.929
ALDH1L2	SHMT1	ENSP00000258494	ENSP00000318868	Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family	Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine	0.964
ALDH1L2	SHMT2	ENSP00000258494	ENSP00000333667	Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family	Serine hydroxymethyltransferase, mitochondrial; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism. Thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. Plays a role in the deubiquitination of target proteins as component of the BRISC complex. Required for IFNAR1 deubiquitination by the BRISC complex; Belongs to the SHMT family	0.969
AMT	ALDH1L2	ENSP00000273588	ENSP00000258494	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family	0.933
AMT	DHFR	ENSP00000273588	ENSP00000396308	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2	0.938
AMT	FTCD	ENSP00000273588	ENSP00000291670	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Formimidoyltransferase-cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family	0.936
AMT	GART	ENSP00000273588	ENSP00000371253	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family	0.952
AMT	MTHFD1	ENSP00000273588	ENSP00000216605	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	C-1-tetrahydrofolate synthase, cytoplasmic; Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family	0.969
AMT	MTHFD2	ENSP00000273588	ENSP00000377617	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency; Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family	0.979
AMT	MTHFD2L	ENSP00000273588	ENSP00000379108	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; Methylenetetrahydrofolate dehydrogenase 2 like	0.976
AMT	MTR	ENSP00000273588	ENSP00000355536	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity); Belongs to the vitamin-B12 dependent methionine synthase family	0.947
AMT	SHMT1	ENSP00000273588	ENSP00000318868	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine	0.988
AMT	SHMT2	ENSP00000273588	ENSP00000333667	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Serine hydroxymethyltransferase, mitochondrial; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism. Thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. Plays a role in the deubiquitination of target proteins as component of the BRISC complex. Required for IFNAR1 deubiquitination by the BRISC complex; Belongs to the SHMT family	0.989

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