| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BCDIN3D | ZC3H10 | ENSP00000335201 | ENSP00000257940 | Pre-miRNA 5’-monophosphate methyltransferase; O-methyltransferase that specifically dimethylates the 5’ monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5’ monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing- methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre- miRNAs | Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5’-GCAGCGC-3’ on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA; Zinc fingers CCCH-type | 0.770 |
| ESYT1 | FPGT | ENSP00000267113 | ENSP00000359935 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family | Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids | 0.633 |
| ESYT1 | RBM6 | ENSP00000267113 | ENSP00000266022 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family | RNA-binding protein 6; Specifically binds poly(G) RNA homopolymers in vitro; G-patch domain containing | 0.629 |
| ESYT1 | ZC3H10 | ENSP00000267113 | ENSP00000257940 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family | Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5’-GCAGCGC-3’ on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA; Zinc fingers CCCH-type | 0.851 |
| ESYT1 | ZFP91 | ENSP00000267113 | ENSP00000339030 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family | E3 ubiquitin-protein ligase ZFP91; Atypical E3 ubiquitin-protein ligase that mediates ’Lys- 63’-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.449 |
| FPGT | ESYT1 | ENSP00000359935 | ENSP00000267113 | Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family | 0.633 |
| FPGT | HHLA1 | ENSP00000359935 | ENSP00000407107 | Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids | HERV-H LTR-associating 1 | 0.593 |
| FPGT | RBM6 | ENSP00000359935 | ENSP00000266022 | Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids | RNA-binding protein 6; Specifically binds poly(G) RNA homopolymers in vitro; G-patch domain containing | 0.632 |
| FPGT | ZC3H10 | ENSP00000359935 | ENSP00000257940 | Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids | Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5’-GCAGCGC-3’ on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA; Zinc fingers CCCH-type | 0.670 |
| FPGT | ZFP91 | ENSP00000359935 | ENSP00000339030 | Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids | E3 ubiquitin-protein ligase ZFP91; Atypical E3 ubiquitin-protein ligase that mediates ’Lys- 63’-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.636 |
| HHLA1 | FPGT | ENSP00000407107 | ENSP00000359935 | HERV-H LTR-associating 1 | Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids | 0.593 |
| HHLA1 | RBM6 | ENSP00000407107 | ENSP00000266022 | HERV-H LTR-associating 1 | RNA-binding protein 6; Specifically binds poly(G) RNA homopolymers in vitro; G-patch domain containing | 0.784 |
| HHLA1 | ZC3H10 | ENSP00000407107 | ENSP00000257940 | HERV-H LTR-associating 1 | Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5’-GCAGCGC-3’ on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA; Zinc fingers CCCH-type | 0.665 |
| HHLA1 | ZFP91 | ENSP00000407107 | ENSP00000339030 | HERV-H LTR-associating 1 | E3 ubiquitin-protein ligase ZFP91; Atypical E3 ubiquitin-protein ligase that mediates ’Lys- 63’-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.665 |
| LAMB4 | ZC3H10 | ENSP00000373433 | ENSP00000257940 | Laminin subunit beta-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5’-GCAGCGC-3’ on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA; Zinc fingers CCCH-type | 0.683 |
| NFYA | ZC3H10 | ENSP00000345702 | ENSP00000257940 | Nuclear transcription factor Y subunit alpha; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5’- CCAAT-3’ box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1 | Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5’-GCAGCGC-3’ on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA; Zinc fingers CCCH-type | 0.723 |
| RBM26 | ZC3H10 | ENSP00000483408 | ENSP00000257940 | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5’-GCAGCGC-3’ on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA; Zinc fingers CCCH-type | 0.681 |
| RBM26 | ZC3H4 | ENSP00000483408 | ENSP00000253048 | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | Zinc finger CCCH domain-containing protein 4; Armadillo-like helical domain containing | 0.634 |
| RBM6 | ESYT1 | ENSP00000266022 | ENSP00000267113 | RNA-binding protein 6; Specifically binds poly(G) RNA homopolymers in vitro; G-patch domain containing | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family | 0.629 |
| RBM6 | FPGT | ENSP00000266022 | ENSP00000359935 | RNA-binding protein 6; Specifically binds poly(G) RNA homopolymers in vitro; G-patch domain containing | Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids | 0.632 |
