| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BCDIN3D | FAM186B | ENSP00000335201 | ENSP00000257894 | Pre-miRNA 5’-monophosphate methyltransferase; O-methyltransferase that specifically dimethylates the 5’ monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5’ monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing- methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre- miRNAs | Protein FAM186B; Family with sequence similarity 186 member B | 0.459 |
| EMC8 | FAM186B | ENSP00000253457 | ENSP00000257894 | ER membrane protein complex subunit 8 | Protein FAM186B; Family with sequence similarity 186 member B | 0.416 |
| FAM186B | BCDIN3D | ENSP00000257894 | ENSP00000335201 | Protein FAM186B; Family with sequence similarity 186 member B | Pre-miRNA 5’-monophosphate methyltransferase; O-methyltransferase that specifically dimethylates the 5’ monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5’ monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing- methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre- miRNAs | 0.459 |
| FAM186B | EMC8 | ENSP00000257894 | ENSP00000253457 | Protein FAM186B; Family with sequence similarity 186 member B | ER membrane protein complex subunit 8 | 0.416 |
| FAM186B | FMNL3 | ENSP00000257894 | ENSP00000335655 | Protein FAM186B; Family with sequence similarity 186 member B | Formin-like protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement; Belongs to the formin homology family | 0.420 |
| FAM186B | MCRS1 | ENSP00000257894 | ENSP00000349640 | Protein FAM186B; Family with sequence similarity 186 member B | Microspherule protein 1; Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. Binds to G-quadruplex structures in mRNA. Binds to RNA homopolymer poly(G) and poly(U) | 0.539 |
| FAM186B | NCKAP5L | ENSP00000257894 | ENSP00000337998 | Protein FAM186B; Family with sequence similarity 186 member B | Nck-associated protein 5-like; Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules. Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation | 0.556 |
| FAM186B | PRELID1 | ENSP00000257894 | ENSP00000302114 | Protein FAM186B; Family with sequence similarity 186 member B | PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1-PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induce [...] | 0.453 |
| FAM186B | PRPF40B | ENSP00000257894 | ENSP00000448073 | Protein FAM186B; Family with sequence similarity 186 member B | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing | 0.440 |
| FAM186B | RBM48 | ENSP00000257894 | ENSP00000265732 | Protein FAM186B; Family with sequence similarity 186 member B | RNA-binding protein 48; RNA binding motif containing | 0.670 |
| FMNL3 | FAM186B | ENSP00000335655 | ENSP00000257894 | Formin-like protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement; Belongs to the formin homology family | Protein FAM186B; Family with sequence similarity 186 member B | 0.420 |
| FMNL3 | PRPF40B | ENSP00000335655 | ENSP00000448073 | Formin-like protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement; Belongs to the formin homology family | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing | 0.489 |
| MCRS1 | FAM186B | ENSP00000349640 | ENSP00000257894 | Microspherule protein 1; Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. Binds to G-quadruplex structures in mRNA. Binds to RNA homopolymer poly(G) and poly(U) | Protein FAM186B; Family with sequence similarity 186 member B | 0.539 |
| NCKAP5L | FAM186B | ENSP00000337998 | ENSP00000257894 | Nck-associated protein 5-like; Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules. Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation | Protein FAM186B; Family with sequence similarity 186 member B | 0.556 |
| PRELID1 | FAM186B | ENSP00000302114 | ENSP00000257894 | PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1-PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induce [...] | Protein FAM186B; Family with sequence similarity 186 member B | 0.453 |
| PRPF40B | FAM186B | ENSP00000448073 | ENSP00000257894 | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing | Protein FAM186B; Family with sequence similarity 186 member B | 0.440 |
| PRPF40B | FMNL3 | ENSP00000448073 | ENSP00000335655 | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing | Formin-like protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement; Belongs to the formin homology family | 0.489 |
| RBM48 | FAM186B | ENSP00000265732 | ENSP00000257894 | RNA-binding protein 48; RNA binding motif containing | Protein FAM186B; Family with sequence similarity 186 member B | 0.670 |
