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STRINGSTRING
PRR4 PRR4 LCN1 LCN1 CSPG5 CSPG5 SDC1 SDC1 LACRT LACRT VTN VTN FBLN2 FBLN2 ZMIZ2 ZMIZ2 FN1 FN1 NID1 NID1 SERPINB10 SERPINB10
"LACRT" - Extracellular glycoprotein lacritin in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
LACRTExtracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells (138 aa)    
Predicted Functional Partners:
CSPG5
Chondroitin sulfate proteoglycan 5; May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation (566 aa)
            
  0.903
SDC1
Syndecan-1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (310 aa)
        
 
  0.796
NID1
Nidogen-1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions (1247 aa)
        
 
  0.785
VTN
Vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway; Endogenous ligands (478 aa)
        
 
  0.755
FBLN2
Fibulin-2; Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN; Fibulins (1231 aa)
            
  0.747
LCN1
Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family (176 aa)
            
  0.700
PRR4
Proline-rich protein 4; Proline rich 4 (134 aa)
            
  0.691
ZMIZ2
Zinc finger MIZ domain-containing protein 2; Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors; Zinc fingers MIZ-type (920 aa)
            
  0.617
FN1
Fibronectin type III domain containing; Endogenous ligands (2477 aa)
        
 
  0.591
SERPINB10
Serpin B10; Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus; Serpin peptidase inhibitors (397 aa)
            
  0.546
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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