node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAAT | FAM189A2 | ENSP00000259407 | ENSP00000257515 | Bile acid-CoA-amino acid N-acyltransferase; Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile aci [...] | Protein FAM189A2; Family with sequence similarity 189 member A2 | 0.626 |
BAAT | TJP2 | ENSP00000259407 | ENSP00000438262 | Bile acid-CoA-amino acid N-acyltransferase; Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile aci [...] | Tight junction protein ZO-2; Plays a role in tight junctions and adherens junctions; Belongs to the MAGUK family | 0.748 |
BAAT | TMC1 | ENSP00000259407 | ENSP00000297784 | Bile acid-CoA-amino acid N-acyltransferase; Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile aci [...] | Transmembrane channel-like protein 1; Probable ion channel required for the normal function of cochlear hair cells; Belongs to the TMC family | 0.647 |
BAAT | TSPO | ENSP00000259407 | ENSP00000379563 | Bile acid-CoA-amino acid N-acyltransferase; Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile aci [...] | Translocator protein; Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides; Belongs to the TspO/BZRP family | 0.548 |
C2orf80 | FAM189A2 | ENSP00000343171 | ENSP00000257515 | Uncharacterized protein C2orf80; Chromosome 2 open reading frame 80 | Protein FAM189A2; Family with sequence similarity 189 member A2 | 0.673 |
FAM189A2 | BAAT | ENSP00000257515 | ENSP00000259407 | Protein FAM189A2; Family with sequence similarity 189 member A2 | Bile acid-CoA-amino acid N-acyltransferase; Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile aci [...] | 0.626 |
FAM189A2 | C2orf80 | ENSP00000257515 | ENSP00000343171 | Protein FAM189A2; Family with sequence similarity 189 member A2 | Uncharacterized protein C2orf80; Chromosome 2 open reading frame 80 | 0.673 |
FAM189A2 | RALGPS2 | ENSP00000257515 | ENSP00000356607 | Protein FAM189A2; Family with sequence similarity 189 member A2 | Ras-specific guanine nucleotide-releasing factor RalGPS2; Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity); Pleckstrin homology domain containing | 0.661 |
FAM189A2 | TJP2 | ENSP00000257515 | ENSP00000438262 | Protein FAM189A2; Family with sequence similarity 189 member A2 | Tight junction protein ZO-2; Plays a role in tight junctions and adherens junctions; Belongs to the MAGUK family | 0.808 |
FAM189A2 | TM4SF18 | ENSP00000257515 | ENSP00000296059 | Protein FAM189A2; Family with sequence similarity 189 member A2 | Transmembrane 4 L six family member 18 | 0.606 |
FAM189A2 | TMC1 | ENSP00000257515 | ENSP00000297784 | Protein FAM189A2; Family with sequence similarity 189 member A2 | Transmembrane channel-like protein 1; Probable ion channel required for the normal function of cochlear hair cells; Belongs to the TMC family | 0.748 |
FAM189A2 | TMEM121 | ENSP00000257515 | ENSP00000376304 | Protein FAM189A2; Family with sequence similarity 189 member A2 | Transmembrane protein 121; May play a role in MAPK signaling; Belongs to the TMEM121 family | 0.770 |
FAM189A2 | TMEM200A | ENSP00000257515 | ENSP00000376224 | Protein FAM189A2; Family with sequence similarity 189 member A2 | Transmembrane protein 200A; Belongs to the TMEM200 family | 0.783 |
FAM189A2 | TSPO | ENSP00000257515 | ENSP00000379563 | Protein FAM189A2; Family with sequence similarity 189 member A2 | Translocator protein; Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides; Belongs to the TspO/BZRP family | 0.802 |
FAM189A2 | ZNF292 | ENSP00000257515 | ENSP00000358590 | Protein FAM189A2; Family with sequence similarity 189 member A2 | Zinc finger protein 292; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.578 |
RALGPS2 | FAM189A2 | ENSP00000356607 | ENSP00000257515 | Ras-specific guanine nucleotide-releasing factor RalGPS2; Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity); Pleckstrin homology domain containing | Protein FAM189A2; Family with sequence similarity 189 member A2 | 0.661 |
RALGPS2 | TM4SF18 | ENSP00000356607 | ENSP00000296059 | Ras-specific guanine nucleotide-releasing factor RalGPS2; Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity); Pleckstrin homology domain containing | Transmembrane 4 L six family member 18 | 0.443 |
RALGPS2 | TMEM121 | ENSP00000356607 | ENSP00000376304 | Ras-specific guanine nucleotide-releasing factor RalGPS2; Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity); Pleckstrin homology domain containing | Transmembrane protein 121; May play a role in MAPK signaling; Belongs to the TMEM121 family | 0.662 |
RALGPS2 | ZNF292 | ENSP00000356607 | ENSP00000358590 | Ras-specific guanine nucleotide-releasing factor RalGPS2; Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity); Pleckstrin homology domain containing | Zinc finger protein 292; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.515 |
TJP2 | BAAT | ENSP00000438262 | ENSP00000259407 | Tight junction protein ZO-2; Plays a role in tight junctions and adherens junctions; Belongs to the MAGUK family | Bile acid-CoA-amino acid N-acyltransferase; Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile aci [...] | 0.748 |