| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C11orf80 | CCDC36 | ENSP00000354227 | ENSP00000391788 | Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance | 0.569 |
| C11orf80 | FAM127A | ENSP00000354227 | ENSP00000257013 | Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member A; Belongs to the FAM127 family | 0.451 |
| CCDC36 | C11orf80 | ENSP00000391788 | ENSP00000354227 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance | Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles | 0.569 |
| CCDC36 | FAM127A | ENSP00000391788 | ENSP00000257013 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member A; Belongs to the FAM127 family | 0.445 |
| CCDC36 | SEZ6L | ENSP00000391788 | ENSP00000248933 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing | 0.682 |
| FAM127A | C11orf80 | ENSP00000257013 | ENSP00000354227 | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member A; Belongs to the FAM127 family | Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles | 0.451 |
| FAM127A | CCDC36 | ENSP00000257013 | ENSP00000391788 | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member A; Belongs to the FAM127 family | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance | 0.445 |
| FAM127A | FAM195A | ENSP00000257013 | ENSP00000305138 | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member A; Belongs to the FAM127 family | MAPK regulated corepressor interacting protein 2; Family with sequence similarity 195, member A | 0.569 |
| FAM127A | GABRA2 | ENSP00000257013 | ENSP00000421828 | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member A; Belongs to the FAM127 family | Gamma-aminobutyric acid receptor subunit alpha-2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.466 |
| FAM127A | RGAG1 | ENSP00000257013 | ENSP00000419786 | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member A; Belongs to the FAM127 family | Retrotransposon Gag-like protein 9; Retrotransposon gag domain containing 1 | 0.780 |
| FAM127A | RGAG4 | ENSP00000257013 | ENSP00000476792 | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member A; Belongs to the FAM127 family | Retrotransposon Gag-like protein 5; Retrotransposon gag domain containing 4 | 0.737 |
| FAM127A | SEZ6L | ENSP00000257013 | ENSP00000248933 | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member A; Belongs to the FAM127 family | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing | 0.443 |
| FAM127A | ZCCHC16 | ENSP00000257013 | ENSP00000340590 | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member A; Belongs to the FAM127 family | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system | 0.645 |
| FAM127A | ZCCHC3 | ENSP00000257013 | ENSP00000484056 | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member A; Belongs to the FAM127 family | Zinc finger CCHC-type containing 3 | 0.550 |
| FAM127A | ZNF280D | ENSP00000257013 | ENSP00000267807 | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member A; Belongs to the FAM127 family | Zinc finger protein 280D; May function as a transcription factor | 0.473 |
| FAM195A | FAM127A | ENSP00000305138 | ENSP00000257013 | MAPK regulated corepressor interacting protein 2; Family with sequence similarity 195, member A | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member A; Belongs to the FAM127 family | 0.569 |
| FAM195A | ZNF280D | ENSP00000305138 | ENSP00000267807 | MAPK regulated corepressor interacting protein 2; Family with sequence similarity 195, member A | Zinc finger protein 280D; May function as a transcription factor | 0.712 |
| GABRA2 | FAM127A | ENSP00000421828 | ENSP00000257013 | Gamma-aminobutyric acid receptor subunit alpha-2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member A; Belongs to the FAM127 family | 0.466 |
| RGAG1 | FAM127A | ENSP00000419786 | ENSP00000257013 | Retrotransposon Gag-like protein 9; Retrotransposon gag domain containing 1 | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member A; Belongs to the FAM127 family | 0.780 |
| RGAG1 | RGAG4 | ENSP00000419786 | ENSP00000476792 | Retrotransposon Gag-like protein 9; Retrotransposon gag domain containing 1 | Retrotransposon Gag-like protein 5; Retrotransposon gag domain containing 4 | 0.400 |
