node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CGA | CRH | ENSP00000482232 | ENSP00000276571 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands | 0.951 |
CGA | FSHB | ENSP00000482232 | ENSP00000416606 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Follitropin subunit beta; Stimulates development of follicle and spermatogenesis in the reproductive organs; Belongs to the glycoprotein hormones subunit beta family | 0.988 |
CGA | FSHR | ENSP00000482232 | ENSP00000384708 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Follicle-stimulating hormone receptor; Receptor for follicle-stimulating hormone or follitropin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily | 0.967 |
CGA | GHRH | ENSP00000482232 | ENSP00000362716 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family | 0.951 |
CGA | GHRHR | ENSP00000482232 | ENSP00000320180 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion; Belongs to the G-protein coupled receptor 2 family | 0.960 |
CGA | GNAS | ENSP00000482232 | ENSP00000360141 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity) | 0.916 |
CGA | GPHA2 | ENSP00000482232 | ENSP00000279168 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism; Belongs to the glycoprotein hormones subunit alpha family | 0.902 |
CGA | POMC | ENSP00000482232 | ENSP00000384092 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Pro-opiomelanocortin; Met-enkephalin- Endogenous opiate; Belongs to the POMC family | 0.985 |
CGA | TSHB | ENSP00000482232 | ENSP00000256592 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism; Endogenous ligands | 0.988 |
CGA | TSHR | ENSP00000482232 | ENSP00000441235 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2-GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism (By similarity); Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily | 0.912 |
CRH | CGA | ENSP00000276571 | ENSP00000482232 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | 0.951 |
CRH | FSHB | ENSP00000276571 | ENSP00000416606 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands | Follitropin subunit beta; Stimulates development of follicle and spermatogenesis in the reproductive organs; Belongs to the glycoprotein hormones subunit beta family | 0.908 |
CRH | FSHR | ENSP00000276571 | ENSP00000384708 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands | Follicle-stimulating hormone receptor; Receptor for follicle-stimulating hormone or follitropin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily | 0.908 |
CRH | GHRH | ENSP00000276571 | ENSP00000362716 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family | 0.978 |
CRH | GHRHR | ENSP00000276571 | ENSP00000320180 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands | Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion; Belongs to the G-protein coupled receptor 2 family | 0.954 |
CRH | GNAS | ENSP00000276571 | ENSP00000360141 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity) | 0.915 |
CRH | GPHA2 | ENSP00000276571 | ENSP00000279168 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism; Belongs to the glycoprotein hormones subunit alpha family | 0.903 |
CRH | POMC | ENSP00000276571 | ENSP00000384092 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands | Pro-opiomelanocortin; Met-enkephalin- Endogenous opiate; Belongs to the POMC family | 0.997 |
CRH | TSHB | ENSP00000276571 | ENSP00000256592 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands | Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism; Endogenous ligands | 0.941 |
CRH | TSHR | ENSP00000276571 | ENSP00000441235 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Endogenous ligands | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2-GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism (By similarity); Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily | 0.913 |