node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARL8B | KIF5B | ENSP00000256496 | ENSP00000307078 | ADP-ribosylation factor-like protein 8B; May play a role in lysosome motility. May play a role in chromosome segregation; ARF GTPase family | Kinesin-1 heavy chain; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes; Kinesins | 0.710 |
ARL8B | KXD1 | ENSP00000256496 | ENSP00000472836 | ADP-ribosylation factor-like protein 8B; May play a role in lysosome motility. May play a role in chromosome segregation; ARF GTPase family | KxDL motif-containing protein 1; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May be involved in the biogenesis of lysosome-related organelles such as melanosomes (By similarity); Belongs to the KXD1 family | 0.665 |
ARL8B | MEF2BNB | ENSP00000256496 | ENSP00000425864 | ADP-ribosylation factor-like protein 8B; May play a role in lysosome motility. May play a role in chromosome segregation; ARF GTPase family | BLOC-1-related complex subunit 8; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor | 0.667 |
ARL8B | PLEKHM2 | ENSP00000256496 | ENSP00000364956 | ADP-ribosylation factor-like protein 8B; May play a role in lysosome motility. May play a role in chromosome segregation; ARF GTPase family | Pleckstrin homology domain-containing family M member 2; May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation. May play a role in lysosomes movement and localization at the cell periphery; Pleckstrin homology domain containing | 0.781 |
ARL8B | RAB2A | ENSP00000256496 | ENSP00000262646 | ADP-ribosylation factor-like protein 8B; May play a role in lysosome motility. May play a role in chromosome segregation; ARF GTPase family | Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex; RAB, member RAS oncogene GTPases | 0.906 |
ARL8B | RAB7A | ENSP00000256496 | ENSP00000265062 | ADP-ribosylation factor-like protein 8B; May play a role in lysosome motility. May play a role in chromosome segregation; ARF GTPase family | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulat [...] | 0.652 |
ARL8B | SSR4 | ENSP00000256496 | ENSP00000317331 | ADP-ribosylation factor-like protein 8B; May play a role in lysosome motility. May play a role in chromosome segregation; ARF GTPase family | Translocon-associated protein subunit delta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins; Belongs to the TRAP-delta family | 0.830 |
ARL8B | SUMF1 | ENSP00000256496 | ENSP00000272902 | ADP-ribosylation factor-like protein 8B; May play a role in lysosome motility. May play a role in chromosome segregation; ARF GTPase family | Sulfatase-modifying factor 1; Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family | 0.681 |
ARL8B | VPS33A | ENSP00000256496 | ENSP00000267199 | ADP-ribosylation factor-like protein 8B; May play a role in lysosome motility. May play a role in chromosome segregation; ARF GTPase family | Vacuolar protein sorting-associated protein 33A; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosom [...] | 0.750 |
ARL8B | VPS41 | ENSP00000256496 | ENSP00000309457 | ADP-ribosylation factor-like protein 8B; May play a role in lysosome motility. May play a role in chromosome segregation; ARF GTPase family | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE- mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal m [...] | 0.737 |
KIF5B | ARL8B | ENSP00000307078 | ENSP00000256496 | Kinesin-1 heavy chain; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes; Kinesins | ADP-ribosylation factor-like protein 8B; May play a role in lysosome motility. May play a role in chromosome segregation; ARF GTPase family | 0.710 |
KIF5B | PLEKHM2 | ENSP00000307078 | ENSP00000364956 | Kinesin-1 heavy chain; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes; Kinesins | Pleckstrin homology domain-containing family M member 2; May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation. May play a role in lysosomes movement and localization at the cell periphery; Pleckstrin homology domain containing | 0.802 |
KIF5B | RAB7A | ENSP00000307078 | ENSP00000265062 | Kinesin-1 heavy chain; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes; Kinesins | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulat [...] | 0.931 |
KXD1 | ARL8B | ENSP00000472836 | ENSP00000256496 | KxDL motif-containing protein 1; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May be involved in the biogenesis of lysosome-related organelles such as melanosomes (By similarity); Belongs to the KXD1 family | ADP-ribosylation factor-like protein 8B; May play a role in lysosome motility. May play a role in chromosome segregation; ARF GTPase family | 0.665 |
KXD1 | MEF2BNB | ENSP00000472836 | ENSP00000425864 | KxDL motif-containing protein 1; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May be involved in the biogenesis of lysosome-related organelles such as melanosomes (By similarity); Belongs to the KXD1 family | BLOC-1-related complex subunit 8; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor | 0.986 |
MEF2BNB | ARL8B | ENSP00000425864 | ENSP00000256496 | BLOC-1-related complex subunit 8; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor | ADP-ribosylation factor-like protein 8B; May play a role in lysosome motility. May play a role in chromosome segregation; ARF GTPase family | 0.667 |
MEF2BNB | KXD1 | ENSP00000425864 | ENSP00000472836 | BLOC-1-related complex subunit 8; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor | KxDL motif-containing protein 1; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May be involved in the biogenesis of lysosome-related organelles such as melanosomes (By similarity); Belongs to the KXD1 family | 0.986 |
MEF2BNB | PLEKHM2 | ENSP00000425864 | ENSP00000364956 | BLOC-1-related complex subunit 8; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor | Pleckstrin homology domain-containing family M member 2; May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation. May play a role in lysosomes movement and localization at the cell periphery; Pleckstrin homology domain containing | 0.596 |
PLEKHM2 | ARL8B | ENSP00000364956 | ENSP00000256496 | Pleckstrin homology domain-containing family M member 2; May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation. May play a role in lysosomes movement and localization at the cell periphery; Pleckstrin homology domain containing | ADP-ribosylation factor-like protein 8B; May play a role in lysosome motility. May play a role in chromosome segregation; ARF GTPase family | 0.781 |
PLEKHM2 | KIF5B | ENSP00000364956 | ENSP00000307078 | Pleckstrin homology domain-containing family M member 2; May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation. May play a role in lysosomes movement and localization at the cell periphery; Pleckstrin homology domain containing | Kinesin-1 heavy chain; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes; Kinesins | 0.802 |