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  • 11.0 [archived version]
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MSMO1 MSMO1 LSS LSS NSDHL NSDHL FDFT1 FDFT1 TM7SF2 TM7SF2 DHCR7 DHCR7 SIGMAR1 SIGMAR1 C14orf1 C14orf1 HSD17B7 HSD17B7 SC5D SC5D SQLE SQLE
"C14orf1" - Probable ergosterol biosynthetic protein 28 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
C14orf1Probable ergosterol biosynthetic protein 28; Chromosome 14 open reading frame 1; Belongs to the ERG28 family (140 aa)    
Predicted Functional Partners:
LSS
Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency; Belongs to the terpene cyclase/mutase family (732 aa)
     
 
  0.924
SIGMAR1
Sigma non-opioid intracellular receptor 1; Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. [...] (223 aa)
     
 
  0.901
FDFT1
Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 (417 aa)
     
 
  0.900
MSMO1
Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family (293 aa)
     
 
  0.885
HSD17B7
3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Short chain dehydrogenase/reductase superfamily (341 aa)
     
 
  0.828
DHCR7
7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family (475 aa)
     
 
  0.791
SQLE
Squalene monooxygenase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway; Belongs to the squalene monooxygenase family (574 aa)
     
 
  0.790
TM7SF2
Delta(14)-sterol reductase; Involved in the conversion of lanosterol to cholesterol (418 aa)
     
 
  0.790
SC5D
Lathosterol oxidase; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol; Belongs to the sterol desaturase family (299 aa)
     
 
  0.789
NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis; Short chain dehydrogenase/reductase superfamily (373 aa)
     
 
  0.768
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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