node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAED1 | FBXL17 | ENSP00000364382 | ENSP00000437464 | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | 0.782 |
AAED1 | RNF122 | ENSP00000364382 | ENSP00000256257 | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins | 0.621 |
AAED1 | ZNF367 | ENSP00000364382 | ENSP00000364405 | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes; Zinc fingers C2H2-type | 0.832 |
CAMLG | RNF122 | ENSP00000297156 | ENSP00000256257 | Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins | 0.733 |
FBXL17 | AAED1 | ENSP00000437464 | ENSP00000364382 | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | 0.782 |
FBXL17 | RNF122 | ENSP00000437464 | ENSP00000256257 | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins | 0.626 |
FBXL17 | ZNF367 | ENSP00000437464 | ENSP00000364405 | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes; Zinc fingers C2H2-type | 0.755 |
MARCH2 | RNF122 | ENSP00000471536 | ENSP00000256257 | E3 ubiquitin-protein ligase MARCH2; E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6; Membrane associated ring-CH-type fingers | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins | 0.605 |
MARCH2 | RNF170 | ENSP00000471536 | ENSP00000445725 | E3 ubiquitin-protein ligase MARCH2; E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6; Membrane associated ring-CH-type fingers | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells; Ring finger proteins | 0.638 |
MARCH2 | UBE2D1 | ENSP00000471536 | ENSP00000363019 | E3 ubiquitin-protein ligase MARCH2; E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6; Membrane associated ring-CH-type fingers | Ubiquitin-conjugating enzyme E2 D1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys-48’-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubi [...] | 0.603 |
RNF122 | AAED1 | ENSP00000256257 | ENSP00000364382 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | 0.621 |
RNF122 | CAMLG | ENSP00000256257 | ENSP00000297156 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins | Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B | 0.733 |
RNF122 | FBXL17 | ENSP00000256257 | ENSP00000437464 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | 0.626 |
RNF122 | MARCH2 | ENSP00000256257 | ENSP00000471536 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins | E3 ubiquitin-protein ligase MARCH2; E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6; Membrane associated ring-CH-type fingers | 0.605 |
RNF122 | RNF170 | ENSP00000256257 | ENSP00000445725 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells; Ring finger proteins | 0.696 |
RNF122 | UBE2D1 | ENSP00000256257 | ENSP00000363019 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins | Ubiquitin-conjugating enzyme E2 D1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys-48’-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubi [...] | 0.592 |
RNF122 | UBE2D2 | ENSP00000256257 | ENSP00000381717 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins | Ubiquitin-conjugating enzyme E2 D2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of [...] | 0.548 |
RNF122 | UBE2D3 | ENSP00000256257 | ENSP00000349722 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins | Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family | 0.609 |
RNF122 | UBE2N | ENSP00000256257 | ENSP00000316176 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical ’Lys-63’-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the ’Lys-63’-linked poly-ubiquitination of P [...] | 0.590 |
RNF122 | ZNF367 | ENSP00000256257 | ENSP00000364405 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins | Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes; Zinc fingers C2H2-type | 0.620 |