HRASLS2 protein (human) - STRING database

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HRASLS2

HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC; HRAS like suppressor family (162 aa)

Predicted Functional Partners:

SAA4

0.552

POU2F3

0.499

OTOP2

0.487

UBAC1

0.483

SPATA45

0.476

OR6K3

0.457

SAA2-SAA4

0.448

CFAP46

0.448

APOL2

0.436

POTEH

0.422

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOL2	HRASLS2	ENSP00000249066	ENSP00000255695	Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins	HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC; HRAS like suppressor family	0.436
APOL2	SAA2-SAA4	ENSP00000249066	ENSP00000485552	Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins	SAA2-SAA4 readthrough	0.515
APOL2	SAA4	ENSP00000249066	ENSP00000278222	Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins	Serum amyloid A-4 protein; Major acute phase reactant. Apolipoprotein of the HDL complex; Belongs to the SAA family	0.561
CFAP46	HRASLS2	ENSP00000357575	ENSP00000255695	Cilia- and flagella-associated protein 46; As part of the central apparatus of the cilium axoneme plays a role in cilium movement; Cilia and flagella associated	HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC; HRAS like suppressor family	0.448
HRASLS2	APOL2	ENSP00000255695	ENSP00000249066	HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC; HRAS like suppressor family	Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins	0.436
HRASLS2	CFAP46	ENSP00000255695	ENSP00000357575	HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC; HRAS like suppressor family	Cilia- and flagella-associated protein 46; As part of the central apparatus of the cilium axoneme plays a role in cilium movement; Cilia and flagella associated	0.448
HRASLS2	OR6K3	ENSP00000255695	ENSP00000357127	HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC; HRAS like suppressor family	Olfactory receptor 6K3; Odorant receptor; Olfactory receptors, family 6	0.457
HRASLS2	OTOP2	ENSP00000255695	ENSP00000332528	HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC; HRAS like suppressor family	Otopetrin-2; Otopetrin 2	0.487
HRASLS2	POTEH	ENSP00000255695	ENSP00000340610	HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC; HRAS like suppressor family	POTE ankyrin domain family member H	0.422
HRASLS2	POU2F3	ENSP00000255695	ENSP00000260264	HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC; HRAS like suppressor family	POU domain, class 2, transcription factor 3; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Regulated the expression of a number of genes such as SPRR2A or placental lactogen	0.499
HRASLS2	SAA2-SAA4	ENSP00000255695	ENSP00000485552	HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC; HRAS like suppressor family	SAA2-SAA4 readthrough	0.448
HRASLS2	SAA4	ENSP00000255695	ENSP00000278222	HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC; HRAS like suppressor family	Serum amyloid A-4 protein; Major acute phase reactant. Apolipoprotein of the HDL complex; Belongs to the SAA family	0.552
HRASLS2	SPATA45	ENSP00000255695	ENSP00000419160	HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC; HRAS like suppressor family	Spermatogenesis-associated protein 45; Spermatogenesis associated 45; Belongs to the SPATA45 family	0.476
HRASLS2	UBAC1	ENSP00000255695	ENSP00000360821	HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC; HRAS like suppressor family	Ubiquitin-associated domain-containing protein 1; Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle	0.483
OR6K3	HRASLS2	ENSP00000357127	ENSP00000255695	Olfactory receptor 6K3; Odorant receptor; Olfactory receptors, family 6	HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC; HRAS like suppressor family	0.457
OR6K3	POTEH	ENSP00000357127	ENSP00000340610	Olfactory receptor 6K3; Odorant receptor; Olfactory receptors, family 6	POTE ankyrin domain family member H	0.513
OR6K3	SPATA45	ENSP00000357127	ENSP00000419160	Olfactory receptor 6K3; Odorant receptor; Olfactory receptors, family 6	Spermatogenesis-associated protein 45; Spermatogenesis associated 45; Belongs to the SPATA45 family	0.585
OTOP2	HRASLS2	ENSP00000332528	ENSP00000255695	Otopetrin-2; Otopetrin 2	HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC; HRAS like suppressor family	0.487
POTEH	HRASLS2	ENSP00000340610	ENSP00000255695	POTE ankyrin domain family member H	HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC; HRAS like suppressor family	0.422
POTEH	OR6K3	ENSP00000340610	ENSP00000357127	POTE ankyrin domain family member H	Olfactory receptor 6K3; Odorant receptor; Olfactory receptors, family 6	0.513

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