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  • 11.0 [archived version]
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TMEM238 TMEM238 GPR146 GPR146 TRHDE TRHDE HGNC:9982 HGNC:9982 RFXAP RFXAP RFX2 RFX2 RFXANK RFXANK CIITA CIITA RFX7 RFX7 RFX5 RFX5 ANKRA2 ANKRA2
"RFXAP" - Regulatory factor X-associated protein in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RFXAPRegulatory factor X-associated protein; Part of the RFX complex that binds to the X-box of MHC II promoters (272 aa)    
Predicted Functional Partners:
RFX5
DNA-binding protein RFX5; Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters; Belongs to the RFX family (616 aa)
       
  0.998
RFXANK
DNA-binding protein RFXANK; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. May also potentiate the activation of RAF1 (By similarity); Ankyrin repeat domain containing (260 aa)
       
  0.982
CIITA
MHC class II transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirem [...] (1131 aa)
         
  0.948
HGNC:9982
MHC class II regulatory factor RFX1; Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter; Belongs to the RFX family (979 aa)
       
 
  0.810
RFX7
DNA-binding protein RFX7; Regulatory factor X family; Belongs to the RFX family (1363 aa)
       
 
  0.699
ANKRA2
Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity); Ankyrin repeat domain containing (313 aa)
       
 
  0.674
TMEM238
Transmembrane protein 238 (176 aa)
           
  0.669
RFX2
DNA-binding protein RFX2; Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5’-GTNRCC(0-3N)RGYAAC-3’ present on promoters. Probably activates transcription of the testis- specific histone gene HIST1H1T (By similarity) (723 aa)
       
 
  0.647
GPR146
Probable G-protein coupled receptor 146; Orphan receptor; G protein-coupled receptors, Class A orphans (333 aa)
           
  0.618
TRHDE
Thyrotropin-releasing hormone-degrading ectoenzyme; Specific inactivation of TRH after its release; Belongs to the peptidase M1 family (1024 aa)
           
  0.614
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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