| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMT | GCSH | ENSP00000273588 | ENSP00000319531 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST); Belongs to the GcvH family | 0.999 |
| AMT | GLDC | ENSP00000273588 | ENSP00000370737 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) | 0.999 |
| AMT | MYBPH | ENSP00000273588 | ENSP00000255416 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Fibronectin type III domain containing | 0.883 |
| CD46 | MYBPH | ENSP00000313875 | ENSP00000255416 | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Fibronectin type III domain containing | 0.841 |
| GCSH | AMT | ENSP00000319531 | ENSP00000273588 | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST); Belongs to the GcvH family | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | 0.999 |
| GCSH | GLDC | ENSP00000319531 | ENSP00000370737 | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST); Belongs to the GcvH family | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) | 0.999 |
| GCSH | MYBPH | ENSP00000319531 | ENSP00000255416 | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST); Belongs to the GcvH family | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Fibronectin type III domain containing | 0.902 |
| GLDC | AMT | ENSP00000370737 | ENSP00000273588 | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | 0.999 |
| GLDC | GCSH | ENSP00000370737 | ENSP00000319531 | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST); Belongs to the GcvH family | 0.999 |
| GLDC | MYBPH | ENSP00000370737 | ENSP00000255416 | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Fibronectin type III domain containing | 0.800 |
| MYBPH | AMT | ENSP00000255416 | ENSP00000273588 | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Fibronectin type III domain containing | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | 0.883 |
| MYBPH | CD46 | ENSP00000255416 | ENSP00000313875 | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Fibronectin type III domain containing | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity | 0.841 |
| MYBPH | GCSH | ENSP00000255416 | ENSP00000319531 | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Fibronectin type III domain containing | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST); Belongs to the GcvH family | 0.902 |
| MYBPH | GLDC | ENSP00000255416 | ENSP00000370737 | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Fibronectin type III domain containing | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) | 0.800 |
| MYBPH | MYH14 | ENSP00000255416 | ENSP00000470298 | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Fibronectin type III domain containing | Myosin-14; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping; Deafness associated genes | 0.750 |
| MYBPH | MYH15 | ENSP00000255416 | ENSP00000273353 | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Fibronectin type III domain containing | Myosin-15; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | 0.767 |
| MYBPH | MYH4 | ENSP00000255416 | ENSP00000255381 | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Fibronectin type III domain containing | Myosin-4; Muscle contraction; Myosin heavy chains | 0.738 |
| MYBPH | MYL1 | ENSP00000255416 | ENSP00000307280 | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Fibronectin type III domain containing | Myosin light chain 1/3, skeletal muscle isoform; Regulatory light chain of myosin. Does not bind calcium; EF-hand domain containing | 0.875 |
| MYBPH | MYLPF | ENSP00000255416 | ENSP00000325239 | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Fibronectin type III domain containing | Myosin light chain, phosphorylatable, fast skeletal muscle; EF-hand domain containing | 0.808 |
| MYBPH | TNNC2 | ENSP00000255416 | ENSP00000361636 | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Fibronectin type III domain containing | Troponin C, skeletal muscle; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments; EF-hand domain containing | 0.778 |
