MTL5 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MTL5

Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family (508 aa)

Predicted Functional Partners:

LIN9

0.767

LIN52

0.745

TSSK3

0.694

SPDYA

0.686

WDR73

0.682

BRIX1

0.644

REC8

0.629

ZNF318

0.591

MSH4

0.583

IQCH

0.557

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRIX1	MTL5	ENSP00000338862	ENSP00000255087	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family	0.644
BRIX1	TSSK3	ENSP00000338862	ENSP00000362634	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Testis-specific serine/threonine-protein kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function	0.664
IQCH	MTL5	ENSP00000336861	ENSP00000255087	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family	0.557
LIN52	LIN9	ENSP00000451812	ENSP00000329102	Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component	Protein lin-9 homolog; Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition; Belongs to the lin-9 family	0.999
LIN52	MTL5	ENSP00000451812	ENSP00000255087	Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component	Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family	0.745
LIN9	LIN52	ENSP00000329102	ENSP00000451812	Protein lin-9 homolog; Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition; Belongs to the lin-9 family	Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component	0.999
LIN9	MTL5	ENSP00000329102	ENSP00000255087	Protein lin-9 homolog; Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition; Belongs to the lin-9 family	Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family	0.767
LIN9	WDR73	ENSP00000329102	ENSP00000387982	Protein lin-9 homolog; Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition; Belongs to the lin-9 family	WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics; WD repeat domain containing	0.506
MSH4	MTL5	ENSP00000263187	ENSP00000255087	MutS protein homolog 4; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis; Belongs to the DNA mismatch repair MutS family	Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family	0.583
MSH4	REC8	ENSP00000263187	ENSP00000482546	MutS protein homolog 4; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis; Belongs to the DNA mismatch repair MutS family	Meiotic recombination protein REC8 homolog; Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity); Belongs to the rad21 family	0.785
MSH4	SPDYA	ENSP00000263187	ENSP00000335628	MutS protein homolog 4; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis; Belongs to the DNA mismatch repair MutS family	Speedy protein A; Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2. Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T- loop that obstructs the substrate-binding cleft prior to kinase activation. Mediates cell survival during the DNA damage process through activation of CDK2; Belongs to the Speedy/Ringo family	0.441
MTL5	BRIX1	ENSP00000255087	ENSP00000338862	Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	0.644
MTL5	IQCH	ENSP00000255087	ENSP00000336861	Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	0.557
MTL5	LIN52	ENSP00000255087	ENSP00000451812	Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family	Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component	0.745
MTL5	LIN9	ENSP00000255087	ENSP00000329102	Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family	Protein lin-9 homolog; Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition; Belongs to the lin-9 family	0.767
MTL5	MSH4	ENSP00000255087	ENSP00000263187	Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family	MutS protein homolog 4; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis; Belongs to the DNA mismatch repair MutS family	0.583
MTL5	REC8	ENSP00000255087	ENSP00000482546	Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family	Meiotic recombination protein REC8 homolog; Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity); Belongs to the rad21 family	0.629
MTL5	SPDYA	ENSP00000255087	ENSP00000335628	Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family	Speedy protein A; Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2. Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T- loop that obstructs the substrate-binding cleft prior to kinase activation. Mediates cell survival during the DNA damage process through activation of CDK2; Belongs to the Speedy/Ringo family	0.686
MTL5	TSSK3	ENSP00000255087	ENSP00000362634	Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family	Testis-specific serine/threonine-protein kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function	0.694
MTL5	WDR73	ENSP00000255087	ENSP00000387982	Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family	WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics; WD repeat domain containing	0.682

page 1 of 2

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2020

Credits

Access

Info

About