| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARIH1 | TRIM47 | ENSP00000369217 | ENSP00000254816 | E3 ubiquitin-protein ligase ARIH1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates- associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin [...] | Tripartite motif containing 47; Ring finger proteins | 0.571 |
| BLMH | TRIM47 | ENSP00000261714 | ENSP00000254816 | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity | Tripartite motif containing 47; Ring finger proteins | 0.544 |
| FBF1 | MRPL38 | ENSP00000324292 | ENSP00000308275 | Fas-binding factor 1; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis | Mitochondrial ribosomal protein L38; Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily | 0.820 |
| FBF1 | TRIM47 | ENSP00000324292 | ENSP00000254816 | Fas-binding factor 1; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis | Tripartite motif containing 47; Ring finger proteins | 0.566 |
| MRPL38 | FBF1 | ENSP00000308275 | ENSP00000324292 | Mitochondrial ribosomal protein L38; Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily | Fas-binding factor 1; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis | 0.820 |
| MRPL38 | TRIM47 | ENSP00000308275 | ENSP00000254816 | Mitochondrial ribosomal protein L38; Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily | Tripartite motif containing 47; Ring finger proteins | 0.650 |
| NBEAL1 | TRIM47 | ENSP00000399903 | ENSP00000254816 | Neurobeachin-like protein 1; Armadillo-like helical domain containing; Belongs to the WD repeat neurobeachin family | Tripartite motif containing 47; Ring finger proteins | 0.533 |
| OR51J1 | TRIM47 | ENSP00000332473 | ENSP00000254816 | Olfactory receptor 51J1; Odorant receptor; Olfactory receptors, family 51 | Tripartite motif containing 47; Ring finger proteins | 0.530 |
| RGS1 | TRIM47 | ENSP00000356429 | ENSP00000254816 | Regulator of G-protein signaling 1; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form | Tripartite motif containing 47; Ring finger proteins | 0.637 |
| RGS2 | TRIM47 | ENSP00000235382 | ENSP00000254816 | Regulator of G-protein signaling 2; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, ther [...] | Tripartite motif containing 47; Ring finger proteins | 0.653 |
| RGS7 | TRIM47 | ENSP00000355523 | ENSP00000254816 | Regulator of G-protein signaling 7; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling | Tripartite motif containing 47; Ring finger proteins | 0.718 |
| TRIM47 | ARIH1 | ENSP00000254816 | ENSP00000369217 | Tripartite motif containing 47; Ring finger proteins | E3 ubiquitin-protein ligase ARIH1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates- associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin [...] | 0.571 |
| TRIM47 | BLMH | ENSP00000254816 | ENSP00000261714 | Tripartite motif containing 47; Ring finger proteins | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity | 0.544 |
| TRIM47 | FBF1 | ENSP00000254816 | ENSP00000324292 | Tripartite motif containing 47; Ring finger proteins | Fas-binding factor 1; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis | 0.566 |
| TRIM47 | MRPL38 | ENSP00000254816 | ENSP00000308275 | Tripartite motif containing 47; Ring finger proteins | Mitochondrial ribosomal protein L38; Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily | 0.650 |
| TRIM47 | NBEAL1 | ENSP00000254816 | ENSP00000399903 | Tripartite motif containing 47; Ring finger proteins | Neurobeachin-like protein 1; Armadillo-like helical domain containing; Belongs to the WD repeat neurobeachin family | 0.533 |
| TRIM47 | OR51J1 | ENSP00000254816 | ENSP00000332473 | Tripartite motif containing 47; Ring finger proteins | Olfactory receptor 51J1; Odorant receptor; Olfactory receptors, family 51 | 0.530 |
| TRIM47 | RGS1 | ENSP00000254816 | ENSP00000356429 | Tripartite motif containing 47; Ring finger proteins | Regulator of G-protein signaling 1; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form | 0.637 |
| TRIM47 | RGS2 | ENSP00000254816 | ENSP00000235382 | Tripartite motif containing 47; Ring finger proteins | Regulator of G-protein signaling 2; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, ther [...] | 0.653 |
| TRIM47 | RGS7 | ENSP00000254816 | ENSP00000355523 | Tripartite motif containing 47; Ring finger proteins | Regulator of G-protein signaling 7; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling | 0.718 |
