node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ELAVL2 | EML5 | ENSP00000380479 | ENSP00000451998 | ELAV-like protein 2; Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR; Belongs to the RRM elav family | Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing | 0.660 |
ELAVL2 | MBNL1 | ENSP00000380479 | ENSP00000282486 | ELAV-like protein 2; Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR; Belongs to the RRM elav family | Muscleblind-like protein 1; Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron [...] | 0.593 |
ELAVL2 | PDE4D | ENSP00000380479 | ENSP00000345502 | ELAV-like protein 2; Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR; Belongs to the RRM elav family | cAMP-specific 3’,5’-cyclic phosphodiesterase 4D; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes; Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily | 0.643 |
ELAVL2 | SLC6A11 | ENSP00000380479 | ENSP00000254488 | ELAV-like protein 2; Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR; Belongs to the RRM elav family | Sodium- and chloride-dependent GABA transporter 3; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily | 0.675 |
ELAVL2 | SLC6A13 | ENSP00000380479 | ENSP00000339260 | ELAV-like protein 2; Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR; Belongs to the RRM elav family | Sodium- and chloride-dependent GABA transporter 2; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport; Solute carriers | 0.554 |
EML5 | ELAVL2 | ENSP00000451998 | ENSP00000380479 | Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing | ELAV-like protein 2; Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR; Belongs to the RRM elav family | 0.660 |
EML5 | PDE4D | ENSP00000451998 | ENSP00000345502 | Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing | cAMP-specific 3’,5’-cyclic phosphodiesterase 4D; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes; Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily | 0.662 |
EML5 | SLC6A11 | ENSP00000451998 | ENSP00000254488 | Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing | Sodium- and chloride-dependent GABA transporter 3; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily | 0.677 |
EML5 | SLC6A13 | ENSP00000451998 | ENSP00000339260 | Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing | Sodium- and chloride-dependent GABA transporter 2; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport; Solute carriers | 0.503 |
GABRA5 | GABRD | ENSP00000335592 | ENSP00000367848 | Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.772 |
GABRA5 | GABRR3 | ENSP00000335592 | ENSP00000481321 | Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Gamma-aminobutyric acid receptor subunit rho-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.722 |
GABRA5 | SLC32A1 | ENSP00000335592 | ENSP00000217420 | Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Solute carriers | 0.502 |
GABRA5 | SLC6A11 | ENSP00000335592 | ENSP00000254488 | Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Sodium- and chloride-dependent GABA transporter 3; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily | 0.671 |
GABRA5 | SLC6A13 | ENSP00000335592 | ENSP00000339260 | Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Sodium- and chloride-dependent GABA transporter 2; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport; Solute carriers | 0.762 |
GABRD | GABRA5 | ENSP00000367848 | ENSP00000335592 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.772 |
GABRD | GABRR3 | ENSP00000367848 | ENSP00000481321 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Gamma-aminobutyric acid receptor subunit rho-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.574 |
GABRD | SLC32A1 | ENSP00000367848 | ENSP00000217420 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Solute carriers | 0.587 |
GABRD | SLC6A11 | ENSP00000367848 | ENSP00000254488 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Sodium- and chloride-dependent GABA transporter 3; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily | 0.673 |
GABRD | SLC6A13 | ENSP00000367848 | ENSP00000339260 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Sodium- and chloride-dependent GABA transporter 2; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport; Solute carriers | 0.734 |
GABRR3 | GABRA5 | ENSP00000481321 | ENSP00000335592 | Gamma-aminobutyric acid receptor subunit rho-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.722 |