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STRINGSTRING
C19orf53 C19orf53 C19orf67 C19orf67 C19orf57 C19orf57 PRSS50 PRSS50 ZSWIM4 ZSWIM4 DYNLL2 DYNLL2 ADM5 ADM5 TTC9 TTC9 C10orf10 C10orf10 CSRNP3 CSRNP3 TMEM65 TMEM65
"ZSWIM4" - Zinc finger SWIM-type containing 4 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZSWIM4Zinc finger SWIM-type containing 4 (989 aa)    
Predicted Functional Partners:
DYNLL2
Dynein light chain 2, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity); Belongs to the dynein light chain family (89 aa)
            
  0.653
PRSS50
Probable threonine protease PRSS50; May be involved in proteolysis through its threonine endopeptidase activity; Belongs to the peptidase S1 family (385 aa)
            
  0.640
TTC9
Tetratricopeptide repeat domain containing; Belongs to the TTC9 family (222 aa)
            
  0.640
C19orf67
UPF0575 protein C19orf67; Chromosome 19 open reading frame 67; Belongs to the UPF0575 family (358 aa)
            
  0.631
CSRNP3
Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits (585 aa)
            
  0.608
C10orf10
Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS (212 aa)
            
  0.588
TMEM65
Transmembrane protein 65; May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contributes to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance (240 aa)
            
  0.571
ADM5
Putative adrenomedullin-5-like protein; Probable non-functional remnant of adrenomedullin-5 (153 aa)
      
   
  0.557
C19orf57
Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57 (637 aa)
            
  0.554
C19orf53
Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy (99 aa)
            
  0.539
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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