| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C8orf44 | ICA1L | ENSP00000428002 | ENSP00000478645 | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | Islet cell autoantigen 1-like protein; Classical BAR domain containing | 0.765 |
| C8orf44 | USP29 | ENSP00000428002 | ENSP00000254181 | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | Ubiquitin specific peptidase 29 | 0.626 |
| CLSPN | USP29 | ENSP00000312995 | ENSP00000254181 | Claspin; Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks | Ubiquitin specific peptidase 29 | 0.787 |
| CLSPN | USP7 | ENSP00000312995 | ENSP00000343535 | Claspin; Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks | Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53- dependent transcription regulation, cell growth repression and apoptosis. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of [...] | 0.830 |
| ICA1L | C8orf44 | ENSP00000478645 | ENSP00000428002 | Islet cell autoantigen 1-like protein; Classical BAR domain containing | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | 0.765 |
| ICA1L | USP29 | ENSP00000478645 | ENSP00000254181 | Islet cell autoantigen 1-like protein; Classical BAR domain containing | Ubiquitin specific peptidase 29 | 0.582 |
| PEG3 | USP29 | ENSP00000326581 | ENSP00000254181 | Paternally-expressed gene 3 protein; Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells; Belongs to the krueppel C2H2-type zinc-finger protein family | Ubiquitin specific peptidase 29 | 0.599 |
| PEG3 | ZIM2 | ENSP00000326581 | ENSP00000468984 | Paternally-expressed gene 3 protein; Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells; Belongs to the krueppel C2H2-type zinc-finger protein family | Zinc finger imprinted 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.410 |
| RGS3 | USP29 | ENSP00000363255 | ENSP00000254181 | Regulator of G-protein signaling 3; Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases; C2 domain containing | Ubiquitin specific peptidase 29 | 0.655 |
| USP29 | C8orf44 | ENSP00000254181 | ENSP00000428002 | Ubiquitin specific peptidase 29 | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | 0.626 |
| USP29 | CLSPN | ENSP00000254181 | ENSP00000312995 | Ubiquitin specific peptidase 29 | Claspin; Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks | 0.787 |
| USP29 | ICA1L | ENSP00000254181 | ENSP00000478645 | Ubiquitin specific peptidase 29 | Islet cell autoantigen 1-like protein; Classical BAR domain containing | 0.582 |
| USP29 | PEG3 | ENSP00000254181 | ENSP00000326581 | Ubiquitin specific peptidase 29 | Paternally-expressed gene 3 protein; Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.599 |
| USP29 | RGS3 | ENSP00000254181 | ENSP00000363255 | Ubiquitin specific peptidase 29 | Regulator of G-protein signaling 3; Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases; C2 domain containing | 0.655 |
| USP29 | USP5 | ENSP00000254181 | ENSP00000229268 | Ubiquitin specific peptidase 29 | Ubiquitin carboxyl-terminal hydrolase 5; Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored ’Lys-48’-linked polyubiquitin disassembly. Binds linear and ’Lys- 63’-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition; Ubiquitin specific peptidases | 0.625 |
| USP29 | USP7 | ENSP00000254181 | ENSP00000343535 | Ubiquitin specific peptidase 29 | Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53- dependent transcription regulation, cell growth repression and apoptosis. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of [...] | 0.623 |
| USP29 | ZIM2 | ENSP00000254181 | ENSP00000468984 | Ubiquitin specific peptidase 29 | Zinc finger imprinted 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.712 |
| USP29 | ZIM3 | ENSP00000254181 | ENSP00000269834 | Ubiquitin specific peptidase 29 | Zinc finger imprinted 3; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.745 |
| USP29 | ZNF264 | ENSP00000254181 | ENSP00000263095 | Ubiquitin specific peptidase 29 | Zinc finger protein 264; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.580 |
| USP5 | USP29 | ENSP00000229268 | ENSP00000254181 | Ubiquitin carboxyl-terminal hydrolase 5; Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored ’Lys-48’-linked polyubiquitin disassembly. Binds linear and ’Lys- 63’-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition; Ubiquitin specific peptidases | Ubiquitin specific peptidase 29 | 0.625 |
